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    Kmt2b lysine methyltransferase 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102550344, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Kmt2bprovided by RGD
    Official Full Name
    lysine methyltransferase 2Bprovided by RGD
    Primary source
    RGD:7678027
    See related
    Ensembl:ENSRNOG00000055525 AllianceGenome:RGD:7678027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mll4; Wbp7; RGD1308331
    Summary
    Predicted to enable histone methyltransferase activity (H3-K4 specific); unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in histone H3-K4 dimethylation; histone H3-K4 monomethylation; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including DNA methylation-dependent heterochromatin assembly; female gamete generation; and histone H3-K4 trimethylation. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 51.0), Spleen (RPKM 46.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt2b in Genome Data Viewer
    Location:
    1q21
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94949144..94969239, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85821700..85840987, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89022889..89042176, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1 Neighboring gene microRNA 3569 Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene uroplakin 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KMT2B-dependent RFK transcription activates the TNF-α/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion. Cao Y, et al. J Mol Cell Cardiol, 2022 Dec. PMID 36162497
    2. Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain. Lee YM, et al. Cancers (Basel), 2020 Dec 4. PMID 33291558, Free PMC Article
    3. Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo. Ansari KI, et al. Br J Cancer, 2012 Jul 10. PMID 22713656, Free PMC Article
    4. Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma. Saigo K, et al. Hum Mutat, 2008 May. PMID 18320596
    5. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Santos MA, et al. Nature, 2014 Oct 2. PMID 25079327, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KMT2B-dependent RFK transcription activates the TNF-alpha/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion.
      Title: KMT2B-dependent RFK transcription activates the TNF-α/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K4 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maternal-to-zygotic transition of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2B
    Names
    WW domain binding protein 7
    histone-lysine N-methyltransferase 2B-like
    lysine (K)-specific methyltransferase 2B
    myeloid/lymphoid or mixed-lineage leukemia 4
    NP_001414070.1
    XP_008757476.1
    XP_038949806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427141.1 → NP_001414070.1  histone-lysine N-methyltransferase 2B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K1E3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94949144..94969239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759254.4 → XP_008757476.1  histone-lysine N-methyltransferase 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8S5
      Conserved Domains (10) summary
      cd05493
      Location:1373 → 1515
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2411 → 2495
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:2575 → 2695
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:2557 → 2713
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:956 → 1003
      zf-CXXC; CXXC zinc finger domain
      cd15589
      Location:1202 → 1248
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:1250 → 1299
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:1336 → 1392
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:1580 → 1684
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      pfam05964
      Location:1733 → 1779
      FYRN; F/Y-rich N-terminus

    2. XM_039093878.2 → XP_038949806.1  histone-lysine N-methyltransferase 2B isoform X2

      Conserved Domains (9) summary
      cd05493
      Location:363 → 505
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:1402 → 1486
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:781 → 1355
      PHA03247; large tegument protein UL36; Provisional
      cd15589
      Location:192 → 238
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:240 → 289
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:326 → 382
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:570 → 674
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      cd19170
      Location:1551 → 1704
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:722 → 769
      FYRN; F/Y-rich N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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