U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MCRIP2 MAPK regulated corepressor interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 84331, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MCRIP2provided by HGNC
    Official Full Name
    MAPK regulated corepressor interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:14142
    See related
    Ensembl:ENSG00000172366 AllianceGenome:HGNC:14142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM195A; C16orf14; c349E10.1
    Summary
    Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 20.5), duodenum (RPKM 19.9) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MCRIP2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (641828..648474)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (645896..652542)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (691828..698474)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene tRNA-Gly (anticodon CCC) 2-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene WD repeat domain 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene ras homolog family member T2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
    2. Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. Wang Y, et al. Circulation, 2018 Jul 3. PMID 29453251
    3. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182
    4. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
    5. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
      Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with family with sequence similarity 195, member A (FAM195A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC15416, MGC104301

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    MAPK regulated corepressor interacting protein 2
    Names
    MAPK regulated co-repressor interacting protein 2
    family with sequence similarity 195, member A
    protein FAM195A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331229.2 → NP_001318158.1  MAPK regulated corepressor interacting protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC001912, BM761884, BQ222343
      UniProtKB/Swiss-Prot
      Q9BUT9
      Conserved Domains (1) summary
      pfam14799
      Location:61 → 123
      FAM195; FAM195 family

    2. NM_001331230.2 → NP_001318159.1  MAPK regulated corepressor interacting protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC001912, BE727113, BM761884
      UniProtKB/Swiss-Prot
      Q9BUT9

    3. NM_138418.4 → NP_612427.2  MAPK regulated corepressor interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_612427.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC001912, BM761884
      Consensus CDS
      CCDS10415.1
      UniProtKB/Swiss-Prot
      Q969E9, Q96KV8, Q9BUT9
      Related
      ENSP00000305138.4, ENST00000307650.9
      Conserved Domains (1) summary
      pfam14799
      Location:61 → 157
      FAM195; FAM195 family

    RNA

    1. NR_138604.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL022341
      Related
      ENST00000491999.5

    2. NR_138605.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL022341

    3. NR_138606.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC007346, BM761884
      Related
      ENST00000474840.5

    4. NR_138607.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC001912, BG489095, BM761884

    5. NR_138608.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC001912, BM761884, DT218216

    6. NR_138609.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL022341, BC001912, DB452069

    7. NR_138610.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AJ709169, BC001912

    8. NR_138611.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL022341
      Related
      ENST00000611328.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      641828..648474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      645896..652542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032371.2: Suppressed sequence

      Description
      NM_032371.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BUT9.2 GenPept UniProtKB/Swiss-Prot:Q9BUT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous