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    vha-11 V-type proton ATPase subunit C [ Caenorhabditis elegans ]

    Gene ID: 177017, updated on 22-May-2024

    Summary

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    Gene symbol
    vha-11
    Gene description
    V-type proton ATPase subunit C
    Primary source
    WormBase:WBGene00006920
    Locus tag
    CELE_Y38F2AL.3
    See related
    AllianceGenome:WB:WBGene00006920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in excretory cell; hypodermis; and intestinal cell. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1) and ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See vha-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (2307815..2314567, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene B9 domain-containing protein 2 Neighboring gene ncRNA Neighboring gene V-type proton ATPase 16 kDa proteolipid subunit 2/3 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. Oka T, et al. J Biol Chem, 2000 Sep 22. PMID 10846178
    2. Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. Oka T, et al. J Biol Chem, 1998 Aug 28. PMID 9712884
    3. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka T, et al. J Biol Chem, 2001 Aug 31. PMID 11441002
    4. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Syntichaki P, et al. Curr Biol, 2005 Jul 12. PMID 16005300
    5. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that V-ATPase mutants has unexpected new roles of V-ATPases in both cellular function and early development.
      Title: Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms?
    2. vacuolar H(+)-ATPase activity is required to establish necrosis-promoting, acidic intracellular conditions that augment the function of executioner aspartyl proteases in dying cells.
      Title: The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit C
    NP_001023451.1
    • Confirmed by transcript evidence
    NP_001367641.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2307815..2314567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028280.6 → NP_001023451.1  V-type proton ATPase subunit C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q869J4, Q9N421, Q9XXU9
      Conserved Domains (2) summary
      cd14785
      Location:58 → 78
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:10 → 373
      V-ATPase_C; V-ATPase subunit C

    2. NM_001380087.1 → NP_001367641.1  V-type proton ATPase subunit C [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl15414
      Location:10 → 98
      V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXU9.1

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