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    pippin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37770, updated on 10-May-2024

    Summary

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    Official Symbol
    pippinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034909
    Locus tag
    Dmel_CG4797
    See related
    AllianceGenome:FB:FBgn0034909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4797; Dmel\CG4797
    Summary
    Enables glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in glucose transmembrane transport and trehalose transport. Is integral component of plasma membrane. Is expressed in adult fat body and adult head. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pippin in Genome Data Viewer
    Location:
    60A2-60A2; 2-105 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23812185..23818327, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19699708..19705850, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Structure specific recognition protein Neighboring gene antisense RNA:CR44807 Neighboring gene uncharacterized protein Neighboring gene NTF2-related export protein 1 Neighboring gene Glycine transporter Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. McMullen E, et al. Front Behav Neurosci, 2020. PMID 33551766, Free PMC Article
    2. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
    3. Evidence for transgenerational metabolic programming in Drosophila. Buescher JL, et al. Dis Model Mech, 2013 Sep. PMID 23649823, Free PMC Article
    4. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Mattila J, et al. Cell Rep, 2015 Oct 13. PMID 26440885
    5. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, et al. Cell, 2018 Jul 26. PMID 29909983, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pippin
    Names
    CG4797-PB
    pippin-PB
    sugar transporter-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23812185..23818327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166625.2 → NP_726368.2  pippin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726368.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGI7, Q8MLQ7, Q9W1J2
      Related
      FBpp0072148
      Conserved Domains (2) summary
      cd06174
      Location:64 → 484
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:89 → 497
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLQ7 Q8MLQ7
    Q9W1J2 Q9W1J2

    Gene LinkOut

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