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    PNLIPRP3 pancreatic lipase related protein 3 [ Homo sapiens (human) ]

    Gene ID: 119548, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PNLIPRP3provided by HGNC
    Official Full Name
    pancreatic lipase related protein 3provided by HGNC
    Primary source
    HGNC:HGNC:23492
    See related
    Ensembl:ENSG00000203837 AllianceGenome:HGNC:23492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in skin (RPKM 1.9) and esophagus (RPKM 0.8) See more
    Orthologs
    all
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    Genomic context

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    See PNLIPRP3 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116427847..116477957)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117322181..117372229)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118187359..118237469)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2854 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:118211885-118212416 Neighboring gene high mobility group box 3 pseudogene 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:118240088-118240799 Neighboring gene NANOG hESC enhancer GRCh37_chr10:118301731-118302261 Neighboring gene RNA, U6 small nuclear 1090, pseudogene Neighboring gene pancreatic lipase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. Saelee P, et al. Asian Pac J Cancer Prev, 2009 Jul-Sep. PMID 19640199
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over expression of pancreatic lipase-related protein 3 is associated with hepatocellular carcinoma.
      Title: Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic lipase-related protein 3
    Names
    PL-RP3
    NP_001011709.2
    XP_011537578.1
    XP_011537579.1
    XP_011537580.1
    XP_011537581.1
    XP_054220729.1
    XP_054220730.1
    XP_054220731.1
    XP_054220732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011709.3 → NP_001011709.2  pancreatic lipase-related protein 3 precursor

      See identical proteins and their annotated locations for NP_001011709.2

      Status: VALIDATED

      Source sequence(s)
      AC011328, BC117224
      Consensus CDS
      CCDS31292.1
      UniProtKB/Swiss-Prot
      Q17RR3
      Related
      ENSP00000358232.3, ENST00000369230.4
      Conserved Domains (3) summary
      cd00707
      Location:52 → 348
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:355 → 467
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:18 → 352
      Lipase; Lipase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      116427847..116477957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539276.2 → XP_011537578.1  pancreatic lipase-related protein 3 isoform X1

      Conserved Domains (2) summary
      cd00707
      Location:52 → 257
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cl00011
      Location:271 → 383
      PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

    2. XM_011539279.2 → XP_011537581.1  pancreatic lipase-related protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011537581.1

      Conserved Domains (2) summary
      cd00707
      Location:1 → 243
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:250 → 362
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

    3. XM_011539278.1 → XP_011537580.1  pancreatic lipase-related protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011537580.1

      Conserved Domains (2) summary
      cd00707
      Location:1 → 243
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:250 → 362
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

    4. XM_011539277.1 → XP_011537579.1  pancreatic lipase-related protein 3 isoform X2

      Conserved Domains (2) summary
      cd00707
      Location:3 → 249
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:256 → 368
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      117322181..117372229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364754.1 → XP_054220729.1  pancreatic lipase-related protein 3 isoform X1

    2. XM_054364757.1 → XP_054220732.1  pancreatic lipase-related protein 3 isoform X3

    3. XM_054364756.1 → XP_054220731.1  pancreatic lipase-related protein 3 isoform X3

    4. XM_054364755.1 → XP_054220730.1  pancreatic lipase-related protein 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17RR3.2 GenPept UniProtKB/Swiss-Prot:Q17RR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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