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    Bmp8a bone morphogenetic protein 8a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680931, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bmp8aprovided by RGD
    Official Full Name
    bone morphogenetic protein 8aprovided by RGD
    Primary source
    RGD:1585858
    See related
    Ensembl:ENSRNOG00000030155 AllianceGenome:RGD:1585858
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including diet induced thermogenesis; energy homeostasis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within germ cell development and spermatogenesis. Predicted to be active in extracellular space. Orthologous to several human genes including BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 3.2), Lung (RPKM 2.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bmp8a in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140874942..140902881, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135589839..135617785, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141007462..141033511, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA55 Neighboring gene small nucleolar RNA SNORA55 Neighboring gene poly(A) binding protein, cytoplasmic 4 Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene ribosomal protein S14, pseudogene 5 Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene microtubule-actin crosslinking factor 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). Cheng H, et al. J Bone Joint Surg Am, 2003 Aug. PMID 12925636
    2. Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Zhao GQ, et al. Development, 1998 Mar. PMID 9463357
    3. Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway. Wu FJ, et al. Reproduction, 2020 Mar. PMID 31940275
    4. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Whittle AJ, et al. Cell, 2012 May 11. PMID 22579288, Free PMC Article
    5. Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Ying Y, et al. Mol Endocrinol, 2000 Jul. PMID 10894154

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.
      Title: Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109432.1 → NP_001102902.1  bone morphogenetic protein 8A precursor

      See identical proteins and their annotated locations for NP_001102902.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS27, D3ZTI5
      Related
      ENSRNOP00000049643.2, ENSRNOT00000045922.3
      Conserved Domains (2) summary
      pfam00019
      Location:298 → 398
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:32 → 248
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140874942..140902881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110766.2 → XP_038966694.1  bone morphogenetic protein 8A isoform X1

      Conserved Domains (2) summary
      cl40434
      Location:120 → 224
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily
      cl02928
      Location:46 → 73
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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