Pnpla6 patatin-like phospholipase domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpla6provided by RGD
Official Full Name: patatin-like phospholipase domain containing 6provided by RGD
Primary source: RGD:1564611
See related: Ensembl:ENSRNOG00000000977 AllianceGenome:RGD:1564611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564611
Summary: Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 66.1), Brain (RPKM 51.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6372284..6401632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1574387..1603735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2068749..2098139)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that NTE/PNPLA6 is involved in the maturation of nonmyelinating Schwann cells during development and de-/remyelination after neuronal injury
Title: NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: patatin-like phospholipase domain-containing protein 6

Names: neuropathy target esterase

NP_001414056.1

EC 3.1.1.5

NP_001414057.1

EC 3.1.1.5

XP_008767227.2

EC 3.1.1.5

XP_008767229.1

EC 3.1.1.5

XP_008767230.1

EC 3.1.1.5

XP_008767231.2

EC 3.1.1.5

XP_008767232.2

EC 3.1.1.5

XP_008767234.1

EC 3.1.1.5

XP_038945821.1

EC 3.1.1.5

XP_038945823.1

EC 3.1.1.5

XP_038945825.1

EC 3.1.1.5

XP_063127495.1

EC 3.1.1.5

XP_063127496.1

EC 3.1.1.5

XP_063127497.1

EC 3.1.1.5

XP_063127498.1

EC 3.1.1.5

XP_063127499.1

EC 3.1.1.5

XP_063127500.1

EC 3.1.1.5

XP_063127501.1

EC 3.1.1.5

XP_063127503.1

EC 3.1.1.5

XP_063127504.1

EC 3.1.1.5

XP_063127505.1

EC 3.1.1.5

XP_063127506.1

EC 3.1.1.5

XP_063127507.1

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427127.1 → NP_001414056.1 patatin-like phospholipase domain-containing protein 6 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012
NM_001427128.1 → NP_001414057.1 patatin-like phospholipase domain-containing protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

6372284..6401632

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769010.4 → XP_008767232.2 patatin-like phospholipase domain-containing protein 6 isoform X12

UniProtKB/TrEMBL

A6KQ10, D3ZRF6

Conserved Domains (4) summary

cd07225
Location:938 → 1243

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:162 → 304

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:943 → 1227

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:609 → 717

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_063271431.1 → XP_063127501.1 patatin-like phospholipase domain-containing protein 6 isoform X10
XM_008769009.4 → XP_008767231.2 patatin-like phospholipase domain-containing protein 6 isoform X12

UniProtKB/TrEMBL

A6KQ10, D3ZRF6

Related

ENSRNOP00000001298.6

Conserved Domains (4) summary

cd07225
Location:938 → 1243

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:162 → 304

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:943 → 1227

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:609 → 717

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_063271436.1 → XP_063127506.1 patatin-like phospholipase domain-containing protein 6 isoform X14
XM_063271434.1 → XP_063127504.1 patatin-like phospholipase domain-containing protein 6 isoform X13

UniProtKB/TrEMBL

A6KQ09
XM_063271430.1 → XP_063127500.1 patatin-like phospholipase domain-containing protein 6 isoform X10
XM_008769012.4 → XP_008767234.1 patatin-like phospholipase domain-containing protein 6 isoform X13

See identical proteins and their annotated locations for XP_008767234.1

UniProtKB/TrEMBL

A6KQ09, A6KQ10

Conserved Domains (4) summary

cd07225
Location:937 → 1242

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:162 → 304

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:942 → 1226

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:609 → 717

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_039089897.2 → XP_038945825.1 patatin-like phospholipase domain-containing protein 6 isoform X15

UniProtKB/TrEMBL

A6KQ10

Conserved Domains (2) summary

cd07225
Location:933 → 1238

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:605 → 713

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_063271437.1 → XP_063127507.1 patatin-like phospholipase domain-containing protein 6 isoform X16
XM_063271433.1 → XP_063127503.1 patatin-like phospholipase domain-containing protein 6 isoform X12

UniProtKB/TrEMBL

D3ZRF6
XM_063271435.1 → XP_063127505.1 patatin-like phospholipase domain-containing protein 6 isoform X13

UniProtKB/TrEMBL

A6KQ09
XM_063271425.1 → XP_063127495.1 patatin-like phospholipase domain-containing protein 6 isoform X1
XM_008769005.4 → XP_008767227.2 patatin-like phospholipase domain-containing protein 6 isoform X7

UniProtKB/TrEMBL

A6KQ10
XM_063271426.1 → XP_063127496.1 patatin-like phospholipase domain-containing protein 6 isoform X2
XM_008769007.4 → XP_008767229.1 patatin-like phospholipase domain-containing protein 6 isoform X6

See identical proteins and their annotated locations for XP_008767229.1

UniProtKB/TrEMBL

A6KQ10

Conserved Domains (4) summary

cd07225
Location:949 → 1254

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:173 → 315

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:954 → 1238

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:620 → 728

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_039089893.2 → XP_038945821.1 patatin-like phospholipase domain-containing protein 6 isoform X9

UniProtKB/TrEMBL

A6KQ10

Conserved Domains (2) summary

cd07225
Location:948 → 1253

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:620 → 728

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_063271427.1 → XP_063127497.1 patatin-like phospholipase domain-containing protein 6 isoform X3
XM_008769008.4 → XP_008767230.1 patatin-like phospholipase domain-containing protein 6 isoform X8

See identical proteins and their annotated locations for XP_008767230.1

UniProtKB/TrEMBL

A6KQ10, M0R715

Related

ENSRNOP00000065231.2

Conserved Domains (4) summary

cd07225
Location:948 → 1253

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

COG0664
Location:173 → 315

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:953 → 1237

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:620 → 728

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_063271428.1 → XP_063127498.1 patatin-like phospholipase domain-containing protein 6 isoform X4
XM_063271429.1 → XP_063127499.1 patatin-like phospholipase domain-containing protein 6 isoform X5
XM_039089895.2 → XP_038945823.1 patatin-like phospholipase domain-containing protein 6 isoform X11

UniProtKB/TrEMBL

A6KQ10

Conserved Domains (2) summary

cd07225
Location:944 → 1249

Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

cd00038
Location:616 → 724

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...