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    Shoc2 SHOC2 leucine-rich repeat scaffold protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309548, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Shoc2provided by RGD
    Official Full Name
    SHOC2 leucine-rich repeat scaffold proteinprovided by RGD
    Primary source
    RGD:1308146
    See related
    Ensembl:ENSRNOG00000015339 AllianceGenome:RGD:1308146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 206.5), Kidney (RPKM 187.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shoc2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262964345..263052898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252958939..253048820)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274700621..274751195)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC120100058 Neighboring gene programmed cell death 4 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene uncharacterized LOC134484116 Neighboring gene BBSome interacting protein 1 Neighboring gene adrenoceptor alpha 2A Neighboring gene uncharacterized LOC120100059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage. Wang J, et al. Mol Med Rep, 2021 Oct. PMID 34368865, Free PMC Article
    2. Expanding the SHOC2 mutation associated phenotype of Noonan syndrome with loose anagen hair: structural brain anomalies and myelofibrosis. Gripp KW, et al. Am J Med Genet A, 2013 Oct. PMID 23918763, Free PMC Article
    3. Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling. Moon BS, et al. Stem Cells, 2011 Feb. PMID 21732489
    4. Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome. Motta M, et al. Hum Mol Genet, 2022 Aug 23. PMID 35348676, Free PMC Article
    5. Shoc2/Sur8 protein regulates neurite outgrowth. Leon G, et al. PLoS One, 2014. PMID 25514808, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sur8 is an antidifferentiation factor that stimulates proliferation for maintenance of self-renewal in NPCs via modulation of the Ras-ERK pathway.
      Title: Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to growth hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat protein SHOC-2
    Names
    protein soc-2 homolog
    protein sur-8 homolog
    soc-2 (suppressor of clear) homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013155.2 → NP_001013173.1  leucine-rich repeat protein SHOC-2

      See identical proteins and their annotated locations for NP_001013173.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      262964345..263052898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080784.2 → XP_038936712.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_039080785.2 → XP_038936713.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_039080788.2 → XP_038936716.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_039080777.2 → XP_038936705.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_039080789.2 → XP_038936717.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYI5
      UniProtKB/TrEMBL
      A6JHX2
      Conserved Domains (3) summary
      PLN03150
      Location:453 → 527
      PLN03150; hypothetical protein; Provisional
      PLN00113
      Location:115 → 483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:240 → 262
      LRR_RI; leucine-rich repeat [structural motif]

    6. XM_063265372.1 → XP_063121442.1  leucine-rich repeat protein SHOC-2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYI5.1 GenPept UniProtKB/Swiss-Prot:Q6AYI5

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