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    Sec24a SEC24 homolog A, COPII coat complex component [ Mus musculus (house mouse) ]

    Gene ID: 77371, updated on 12-May-2024

    Summary

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    Official Symbol
    Sec24aprovided by MGI
    Official Full Name
    SEC24 homolog A, COPII coat complex componentprovided by MGI
    Primary source
    MGI:MGI:1924621
    See related
    Ensembl:ENSMUSG00000036391 AllianceGenome:MGI:1924621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within cholesterol homeostasis; positive regulation of protein secretion; and regulation of cholesterol transport. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum; and membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in embryo. Orthologous to human SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 7.6), liver adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec24a in Genome Data Viewer
    Location:
    11 B1.3; 11 31.28 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51583090..51649172, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51692263..51757161, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene STARR-seq mESC enhancer starr_29425 Neighboring gene predicted gene, 30058 Neighboring gene STARR-seq mESC enhancer starr_29426 Neighboring gene STARR-positive B cell enhancer ABC_E6981 Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene trafficking protein particle complex 2B Neighboring gene STARR-seq mESC enhancer starr_29428 Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene jade family PHD finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E10673 Neighboring gene predicted gene, 30110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Chen XW, et al. Elife, 2013 Apr 9. PMID 23580231, Free PMC Article
    2. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345
    3. The COPII cargo adapter SEC24C is essential for neuronal homeostasis. Wang B, et al. J Clin Invest, 2018 Aug 1. PMID 29939162, Free PMC Article
    4. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 9430090N21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec24A
    Names
    SEC24-related protein A
    Sec24 related gene family, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290785.1 → NP_001277714.1  protein transport protein Sec24A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK029139, AK163254, AL645602, BC096594
      Consensus CDS
      CCDS70181.1
      UniProtKB/TrEMBL
      A2AA71
      Related
      ENSMUSP00000044370.6, ENSMUST00000038210.12
      Conserved Domains (6) summary
      cd01479
      Location:497 → 739
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:960 → 1035
      Gelsolin; Gelsolin repeat
      pfam04503
      Location:7 → 177
      SSDP; Single-stranded DNA binding protein, SSDP
      pfam04810
      Location:424 → 460
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:839 → 934
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:740 → 824
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    2. NM_175255.3 → NP_780464.2  protein transport protein Sec24A isoform 1

      See identical proteins and their annotated locations for NP_780464.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029139, AK163254, AL645602, BG065014, CJ055291
      Consensus CDS
      CCDS24660.2
      UniProtKB/Swiss-Prot
      A2AA70, A2AA73, A4FUV4, Q3TQ05, Q3TRG7, Q3U2P1, Q8BIS0
      Related
      ENSMUSP00000104725.3, ENSMUST00000109097.9
      Conserved Domains (6) summary
      cd01479
      Location:498 → 740
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:961 → 1036
      Gelsolin; Gelsolin repeat
      pfam04503
      Location:7 → 177
      SSDP; Single-stranded DNA binding protein, SSDP
      pfam04810
      Location:425 → 461
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:840 → 935
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:741 → 825
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51583090..51649172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314833.3 → XP_017170322.1  protein transport protein Sec24A isoform X1

      UniProtKB/TrEMBL
      A2AA72
      Related
      ENSMUSP00000068065.5, ENSMUST00000064297.5
      Conserved Domains (2) summary
      PHA03247
      Location:5 → 367
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:297 → 589
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

    RNA

    1. XR_388555.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2P1.1 GenPept UniProtKB/Swiss-Prot:Q3U2P1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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