UTS2 urotensin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: UTS2provided by HGNC
Official Full Name: urotensin 2provided by HGNC
Primary source: HGNC:HGNC:12636
See related: Ensembl:ENSG00000049247 MIM:604097; AllianceGenome:HGNC:12636
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UII; U-II; UCN2; PRO1068
Summary: This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (7847612..7913249, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (7378659..7444444, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (7907672..7913551, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
Title: Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
Title: Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
Urotensin II level is elevated in inflammatory bowel disease patients.
Title: Urotensin II level is elevated in inflammatory bowel disease patients.
Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behcet's Disease.
Title: Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet's Disease.
Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
Title: Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
Title: Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
Title: Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
Title: Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
positive correlation with autophagic marker LC3II in placentas of preeclampsia patients
Title: Expression of urotensin II is associated with placental autophagy in patients with severe preeclampsia.
Study findings suggest that UT-2 has a high potential as a vasoconstrictor agent in human bodies and its level increases through a bolus or continuous infusion of 5-fluorouracil (5-FU). Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis.
Title: Role of Urotensin-2 in 5-Fluorouracil-Related Arterial Vasoconstriction in Cancer Patients.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urotensin-2

Names: prepro U-II; urotensin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006786.4 → NP_006777.1 urotensin-2 isoform b preproprotein

See identical proteins and their annotated locations for NP_006777.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes a shorter preproprotein isoform (b) of 124 amino acids with a different amino-terminal end compared to isoform a. The mature peptide is identical for both transcript variants.

Source sequence(s)

AF104118, AY358375, Z98884

Consensus CDS

CCDS91.1

UniProtKB/Swiss-Prot

O95399, Q5H8X7, Q6UXF6, Q9UKP7

UniProtKB/TrEMBL

Q5H8X8

Related

ENSP00000355163.5, ENST00000361696.10

Conserved Domains (1) summary

pfam02083
Location:113 → 124

Urotensin_II; Urotensin II
NM_021995.2 → NP_068835.1 urotensin-2 isoform a preproprotein

See identical proteins and their annotated locations for NP_068835.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes a longer preproprotein isoform (a) of 139 amino acids with a different amino-terminal end compared to isoform b. The mature peptide is identical for both transcript variants.

Source sequence(s)

AF140630, AY358375, BC126443

Consensus CDS

CCDS90.1

UniProtKB/Swiss-Prot

O95399

UniProtKB/TrEMBL

A0AVP6

Related

ENSP00000054668.5, ENST00000054668.5

Conserved Domains (1) summary

pfam02083
Location:128 → 139

Urotensin_II; Urotensin II