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    Ostf1 osteoclast stimulating factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259275, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ostf1provided by RGD
    Official Full Name
    osteoclast stimulating factor 1provided by RGD
    Primary source
    RGD:628849
    See related
    Ensembl:ENSRNOG00000012156 AllianceGenome:RGD:628849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sh3d3
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Orthologous to human OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 563.2), Spleen (RPKM 515.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ostf1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (225428661..225475851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (216002037..216049226, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (234749568..234796739)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RNA binding protein with serine rich domain 1, pseudogene 3 Neighboring gene ribosomal protein S15, pseudogene 7 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene uncharacterized LOC134485209 Neighboring gene carnosine N-methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SH3P2 in complex with Cbl and Src. Szymkiewicz I, et al. FEBS Lett, 2004 May 7. PMID 15135048
    2. Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Sparks AB, et al. Nat Biotechnol, 1996 Jun. PMID 9630982
    3. Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. Moser K, et al. J Proteome Res, 2006 Jan. PMID 16396499
    4. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Barallobre-Barreiro J, et al. Cardiovasc Res, 2016 Jun 1. PMID 27068509, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    osteoclast-stimulating factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148892.4 → NP_683690.2  osteoclast-stimulating factor 1

      See identical proteins and their annotated locations for NP_683690.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6P686, Q8K3X7
      UniProtKB/TrEMBL
      A0A8L2Q834, A6I0J9
      Related
      ENSRNOP00000016871.7, ENSRNOT00000016871.8
      Conserved Domains (4) summary
      cd11772
      Location:16 → 68
      SH3_OSTF1; Src Homology 3 domain of metazoan osteoclast stimulating factor 1
      cd00204
      Location:75 → 189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:77 → 170
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:76 → 103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      225428661..225475851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282375.1 → XP_063138445.1  osteoclast-stimulating factor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P686.1 GenPept UniProtKB/Swiss-Prot:Q6P686

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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