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    Prss56 serine protease 56 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363274, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Prss56provided by RGD
    Official Full Name
    serine protease 56provided by RGD
    Primary source
    RGD:1563955
    See related
    Ensembl:ENSRNOG00000029865 AllianceGenome:RGD:1563955
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563955
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation; positive regulation of leukocyte chemotaxis; and proteolysis. Predicted to act upstream of or within camera-type eye development. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in isolated microphthalmia 6. Orthologous to human PRSS56 (serine protease 56). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 4.4), Heart (RPKM 1.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prss56 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95289984..95307877)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87842806..87859978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94278981..94284111)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase 3, intestine, not Mn requiring Neighboring gene endothelin converting enzyme-like 1 Neighboring gene uncharacterized LOC134480403 Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene cholinergic receptor nicotinic gamma subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes. Wittmann G, et al. J Comp Neurol, 2018 Oct 15. PMID 30242838, Free PMC Article
    2. Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease. Gal A, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397065, Free PMC Article
    3. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nair KS, et al. Nat Genet, 2011 Jun. PMID 21532570, Free PMC Article
    4. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the variable, inversely correlating expression of Prss56 and Pomc reflect periodically oscillating gene expression in tanycytes rather than stable expression levels that vary between individual rats
      Title: Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PRSS56 protease, serine, 56; serine protease 56
    Names
    protease, serine, 56

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95289984..95307877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267933.1 → XP_063124003.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    2. XM_063267924.1 → XP_063123994.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    3. XM_063267929.1 → XP_063123999.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    4. XM_063267931.1 → XP_063124001.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    5. XM_063267922.1 → XP_063123992.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    6. XM_063267921.1 → XP_063123991.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    7. XM_063267923.1 → XP_063123993.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    8. XM_063267928.1 → XP_063123998.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    9. XM_063267919.1 → XP_063123989.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    10. XM_063267932.1 → XP_063124002.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    11. XM_063267925.1 → XP_063123995.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    12. XM_063267926.1 → XP_063123996.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    13. XM_063267930.1 → XP_063124000.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    14. XM_039084699.2 → XP_038940627.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8
      Conserved Domains (1) summary
      cd00190
      Location:112 → 342
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    15. XM_063267917.1 → XP_063123987.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    16. XM_063267927.1 → XP_063123997.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    17. XM_063267918.1 → XP_063123988.1  serine protease 56

      UniProtKB/TrEMBL
      A0A8I6G9L9, D3ZQJ8

    RNA

    1. XR_010054851.1 RNA Sequence

    2. XR_010054852.1 RNA Sequence

    3. XR_005489287.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134586.1: Suppressed sequence

      Description
      NM_001134586.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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