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    Psrc1 proline and serine rich coiled-coil 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691380, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Psrc1provided by RGD
    Official Full Name
    proline and serine rich coiled-coil 1provided by RGD
    Primary source
    RGD:1585037
    See related
    Ensembl:ENSRNOG00000020013 AllianceGenome:RGD:1585037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including mitotic metaphase plate congression; positive regulation of nitrogen compound metabolic process; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including midbody; nucleoplasm; and spindle. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with spindle microtubule and spindle pole. Orthologous to human PSRC1 (proline and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 21.3), Thymus (RPKM 12.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psrc1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198710427..198715001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196022361..196026874)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211176437..211181078)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sortilin 1 Neighboring gene uncharacterized LOC134485672 Neighboring gene myosin binding protein H-like Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene uncharacterized LOC108350091 Neighboring gene seryl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury. Yao C, et al. Glia, 2021 Oct. PMID 34115425
    2. Identification of a novel mouse p53 target gene DDA3. Lo PK, et al. Oncogene, 1999 Dec 16. PMID 10618717
    3. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. Jang CY, et al. J Cell Biol, 2008 Apr 21. PMID 18411309, Free PMC Article
    4. p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway. Hsieh PC, et al. Oncogene, 2007 Jul 26. PMID 17310996
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.
      Title: Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125042

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proline/serine-rich coiled-coil protein 1
    Names
    proline/serine-rich coiled-coil 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044302.1 → NP_001037767.1  proline/serine-rich coiled-coil protein 1

      See identical proteins and their annotated locations for NP_001037767.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105874
      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Related
      ENSRNOP00000052733.1, ENSRNOT00000055880.3
      Conserved Domains (1) summary
      pfam15259
      Location:10 → 124
      GTSE1_N; G-2 and S-phase expressed 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198710427..198715001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282592.1 → XP_063138662.1  proline/serine-rich coiled-coil protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00

    2. XM_006233179.4 → XP_006233241.1  proline/serine-rich coiled-coil protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006233241.1

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Conserved Domains (1) summary
      pfam15259
      Location:10 → 124
      GTSE1_N; G-2 and S-phase expressed 1

    3. XM_006233176.5 → XP_006233238.1  proline/serine-rich coiled-coil protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006233238.1

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Conserved Domains (1) summary
      pfam15259
      Location:10 → 124
      GTSE1_N; G-2 and S-phase expressed 1

    4. XM_006233177.4 → XP_006233239.2  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASD1
      Conserved Domains (2) summary
      pfam05109
      Location:182 → 348
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15259
      Location:61 → 175
      GTSE1_N; G-2 and S-phase expressed 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR66.1 GenPept UniProtKB/Swiss-Prot:Q3KR66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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