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    Trip11 thyroid hormone receptor interactor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314393, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Trip11provided by RGD
    Official Full Name
    thyroid hormone receptor interactor 11provided by RGD
    Primary source
    RGD:1586166
    See related
    Ensembl:ENSRNOG00000005292 AllianceGenome:RGD:1586166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including Golgi ribbon formation; protein localization to ciliary membrane; and vesicle tethering to Golgi. Predicted to act upstream of or within animal organ development and protein glycosylation. Located in inner acrosomal membrane and outer acrosomal membrane. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 158.5), Heart (RPKM 151.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trip11 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126760263..126832619, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120995242..121067693, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125741520..125812926, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene tandem C2 domains, nuclear Neighboring gene fibulin 5 Neighboring gene uncharacterized LOC120103604 Neighboring gene ribosomal protein L37A, pseudogene 6 Neighboring gene ataxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia. Wehrle A, et al. JCI Insight, 2019 Feb 7. PMID 30728324, Free PMC Article
    2. Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210. Sato K, et al. Mol Biol Cell, 2015 Feb 1. PMID 25473115, Free PMC Article
    3. GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Kierszenbaum AL, et al. Dev Dyn, 2011 Mar. PMID 21337470, Free PMC Article
    4. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. Follit JA, et al. PLoS Genet, 2008 Dec. PMID 19112494, Free PMC Article
    5. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. Smits P, et al. N Engl J Med, 2010 Jan 21. PMID 20089971, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle tethering to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inner acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyroid receptor-interacting protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412193.2 → NP_001399122.1  thyroid receptor-interacting protein 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZKA2
      Related
      ENSRNOP00000077357.1, ENSRNOT00000096337.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      126760263..126832619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240470.5 → XP_006240532.1  thyroid receptor-interacting protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKA2, D4ABD7
      Related
      ENSRNOP00000007061.8
      Conserved Domains (1) summary
      COG1196
      Location:312 → 1162
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039112358.2 → XP_038968286.1  thyroid receptor-interacting protein 11 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:6 → 739
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10375
      Location:1278 → 1323
      GRAB; GRIP-related Arf-binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191772.1: Suppressed sequence

      Description
      NM_001191772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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