Il16 interleukin 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il16provided by RGD
Official Full Name: interleukin 16provided by RGD
Primary source: RGD:1583872
See related: Ensembl:ENSRNOG00000011680 AllianceGenome:RGD:1583872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in several processes, including induction of positive chemotaxis; leukocyte chemotaxis; and positive regulation of cytokine production. Predicted to act upstream of or within positive regulation of chemokine production and positive regulation of neutrophil activation. Predicted to be located in several cellular components, including Flemming body; focal adhesion; and nuclear speck. Biomarker of borna disease; glioblastoma; and periodontal disease. Human ortholog(s) of this gene implicated in asthma and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 123.3), Spleen (RPKM 109.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (147026852..147127177, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (137617702..137718022, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (145781923..145881538, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p21WAF1 was required for the induction of p38MAPK-mediated MMP-9 expression via activation of the Sp-1 binding motif, which led to migration and invasion of vascular smooth muscle cells interacting with IL-16/CD4.
Title: p21WAF1 Is Required for Interleukin-16-Induced Migration and Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9 Pathway.
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
Title: Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
taken together, robust IL-16+ cell accumulation in the nervous system and its temporal correlation with severity of neurological signs in experimental autoimmune neuritis (EAN might suggest a pathological role of IL-16 in EAN
Title: Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats.
IL-16 immunoreactivity is a putative marker of a monocytic subset in rat gliomas in vivo and may be a novel factor in the regulation of the local inflammatory milieu and tumor progression.
Title: Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors.

Submit: New GeneRIF Correction

General gene information

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Markers

BE106667 (e-PCR)
- UniSTS:246362

RH132109 (e-PCR)
- UniSTS:215392

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CD4 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-interleukin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105749.1 → NP_001099219.1 pro-interleukin-16

See identical proteins and their annotated locations for NP_001099219.1

Status: PROVISIONAL

Source sequence(s)

CH473980

UniProtKB/TrEMBL

A6JCM5, D4A4I9

Related

ENSRNOP00000016289.4, ENSRNOT00000016289.5

Conserved Domains (2) summary

smart00228
Location:1227 → 1311

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1105 → 1182

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

147026852..147127177 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588676.3 → XP_017444165.1 pro-interleukin-16 isoform X5
XM_017588678.3 → XP_017444167.1 pro-interleukin-16 isoform X6
XM_017588673.3 → XP_017444162.1 pro-interleukin-16 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZI8

Related

ENSRNOP00000083582.1
XM_063266338.1 → XP_063122408.1 pro-interleukin-16 isoform X4

UniProtKB/TrEMBL

A6JCM5, D4A4I9
XM_017588675.3 → XP_017444164.1 pro-interleukin-16 isoform X3
XM_008759600.4 → XP_008757822.1 pro-interleukin-16 isoform X4

See identical proteins and their annotated locations for XP_008757822.1

UniProtKB/TrEMBL

A6JCM5, D4A4I9

Conserved Domains (2) summary

smart00228
Location:1227 → 1311

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1105 → 1182

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006229488.5 → XP_006229550.1 pro-interleukin-16 isoform X1

UniProtKB/TrEMBL

A0A8I6AF93

Related

ENSRNOP00000091335.1

Conserved Domains (2) summary

smart00228
Location:1329 → 1413

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1207 → 1284

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039112275.2 → XP_038968203.1 pro-interleukin-16 isoform X7

Conserved Domains (1) summary

cd00992
Location:294 → 369

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...