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    Fgr FGR proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79113, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fgrprovided by RGD
    Official Full Name
    FGR proto-oncogene, Src family tyrosine kinaseprovided by RGD
    Primary source
    RGD:621319
    See related
    Ensembl:ENSRNOG00000009912 AllianceGenome:RGD:621319
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p55-Fgr
    Summary
    Enables protein tyrosine kinase activity. Predicted to be involved in several processes, including defense response to other organism; protein phosphorylation; and regulation of kinase activity. Predicted to act upstream of or within bone mineralization and skeletal system morphogenesis. Located in cytosol and plasma membrane. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 194.9), Lung (RPKM 104.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgr in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150473767..150503524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145189814..145219571)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151172189..151199746)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A Neighboring gene uncharacterized LOC120102995 Neighboring gene uncharacterized LOC108351145 Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene uncharacterized LOC120102997 Neighboring gene WASP family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein. Brunati AM, et al. Eur J Biochem, 1995 Apr 1. PMID 7744027
    2. The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Shen K, et al. Sci Signal, 2018 Oct 23. PMID 30352950
    3. The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. Lee JH, et al. J Immunol, 2011 Aug 15. PMID 21746961, Free PMC Article
    4. Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase. Axelsson L, et al. Exp Cell Res, 2000 Apr 10. PMID 10739672
    5. Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity. Yan SR, et al. FEBS Lett, 1996 Feb 12. PMID 8603737

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
      Title: The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.
    2. findings provide the first description of a mechanism for activation of phospholipase D2 in a physiological setting and of a role for Fyn and Fgr in Fc epsilon RI-mediated signaling.
      Title: Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Fc-gamma receptor I complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables immunoglobulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in myoblast proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fgr
    Names
    Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
    Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
    feline Gardner-Rasheed sarcoma viral oncogene
    proto-oncogene c-Fgr
    proto-oncogene tyrosine-protein kinase Fgr
    NP_077059.2
    XP_006239141.1
    XP_006239142.1
    XP_006239143.1
    XP_006239144.1
    XP_038966752.1
    XP_038966753.1
    XP_038966754.1
    XP_038966755.1
    XP_038966757.1
    XP_063144531.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024145.3 → NP_077059.2  tyrosine-protein kinase Fgr

      See identical proteins and their annotated locations for NP_077059.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Related
      ENSRNOP00000013779.3, ENSRNOT00000013778.6
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      150473767..150503524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239080.5 → XP_006239142.1  tyrosine-protein kinase Fgr isoform X1

      See identical proteins and their annotated locations for XP_006239142.1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039110826.2 → XP_038966754.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006239081.5 → XP_006239143.1  tyrosine-protein kinase Fgr isoform X1

      See identical proteins and their annotated locations for XP_006239143.1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006239082.5 → XP_006239144.1  tyrosine-protein kinase Fgr isoform X1

      See identical proteins and their annotated locations for XP_006239144.1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039110829.2 → XP_038966757.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    6. XM_039110825.2 → XP_038966753.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    7. XM_039110824.2 → XP_038966752.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    8. XM_006239079.5 → XP_006239141.1  tyrosine-protein kinase Fgr isoform X1

      See identical proteins and their annotated locations for XP_006239141.1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    9. XM_039110827.2 → XP_038966755.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
      Conserved Domains (3) summary
      cd10367
      Location:128 → 228
      SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
      cl17036
      Location:68 → 125
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:255 → 502
      PKc_like; Protein Kinases, catalytic domain

    10. XM_063288461.1 → XP_063144531.1  tyrosine-protein kinase Fgr isoform X1

      UniProtKB/Swiss-Prot
      Q63206, Q6P6U0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6U0.1 GenPept UniProtKB/Swiss-Prot:Q6P6U0

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