Ubxn4 UBX domain protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubxn4provided by RGD
Official Full Name: UBX domain protein 4provided by RGD
Primary source: RGD:1307451
See related: Ensembl:ENSRNOG00000003625 AllianceGenome:RGD:1307451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ubxd2
Summary: Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 244.8), Kidney (RPKM 222.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (42292346..42324928)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (39740064..39772493)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (44956963..44989653)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137406 (e-PCR)
- UniSTS:219494

RH127748 (e-PCR)
- UniSTS:211058

RH138579 (e-PCR)
- UniSTS:220666

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UBX domain-containing protein 4

Names: UBX domain containing 2; UBX domain-containing protein 2; erasin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012025.2 → NP_001012025.1 UBX domain-containing protein 4

See identical proteins and their annotated locations for NP_001012025.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5HZY0

UniProtKB/TrEMBL

A6IBW9, A6IBX0

Related

ENSRNOP00000096311.1, ENSRNOT00000113122.1

Conserved Domains (2) summary

smart00166
Location:318 → 393

UBX; Domain present in ubiquitin-regulatory proteins

cl00388
Location:4 → 113

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

42292346..42324928

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249699.4 → XP_006249761.1 UBX domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZL25, A6IBX0

Related

ENSRNOP00000078558.1

Conserved Domains (2) summary

smart00166
Location:319 → 394

UBX; Domain present in ubiquitin-regulatory proteins

cl00388
Location:4 → 113

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
XM_039090690.2 → XP_038946618.1 UBX domain-containing protein 4 isoform X2

UniProtKB/TrEMBL

A6IBX0

Related

ENSRNOP00000079987.1

Conserved Domains (2) summary

cl00388
Location:4 → 113

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

cl28922
Location:318 → 355

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_063272285.1 → XP_063128355.1 UBX domain-containing protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I5ZNR5