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    Mtss1 MTSS I-BAR domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362918, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mtss1provided by RGD
    Official Full Name
    MTSS I-BAR domain containing 1provided by RGD
    Primary source
    RGD:1309883
    See related
    Ensembl:ENSRNOG00000009001 AllianceGenome:RGD:1309883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including actin binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and urogenital system development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Predicted to be located in adherens junction and cytoplasm. Predicted to be active in actin cytoskeleton. Predicted to be intrinsic component of the cytoplasmic side of the plasma membrane. Orthologous to human MTSS1 (MTSS I-BAR domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 251.7), Heart (RPKM 218.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtss1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (92378228..92517444, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (90488751..90628007, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (98820799..98960878, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC120093662 Neighboring gene uncharacterized LOC134479913 Neighboring gene uncharacterized LOC134479912 Neighboring gene uncharacterized LOC134479604 Neighboring gene uncharacterized LOC134479915

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteome analysis of actin filament-associated proteins in the postnatal rat cerebellum. Shi N, et al. Neuroscience, 2012 Dec 27. PMID 23032931
    2. Structural basis for the actin-binding function of missing-in-metastasis. Lee SH, et al. Structure, 2007 Feb. PMID 17292833, Free PMC Article
    3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Woodings JA, et al. Biochem J, 2003 Apr 15. PMID 12570871, Free PMC Article
    4. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. Mattila PK, et al. J Biol Chem, 2003 Mar 7. PMID 12482861
    5. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. Yamagishi A, et al. J Biol Chem, 2004 Apr 9. PMID 14752106

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adherens junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adherens junction maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to fluid shear stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glomerulus morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerulus morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephric tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nephron tubule epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal tubule morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein MTSS 1
    Names
    MTSS1, I-BAR domain containing
    metastasis suppressor 1
    metastasis suppressor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130563.1 → NP_001124035.1  protein MTSS 1

      See identical proteins and their annotated locations for NP_001124035.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HRL5, A6HRL7, D3ZYM5
      Related
      ENSRNOP00000011984.4, ENSRNOT00000011984.6
      Conserved Domains (1) summary
      cd07643
      Location:38 → 272
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      92378228..92517444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263852.1 → XP_063119922.1  protein MTSS 1 isoform X12

      UniProtKB/TrEMBL
      A6HRL7

    2. XM_063263849.1 → XP_063119919.1  protein MTSS 1 isoform X8

      UniProtKB/TrEMBL
      A6HRL7

    3. XM_063263846.1 → XP_063119916.1  protein MTSS 1 isoform X4

      UniProtKB/TrEMBL
      A6HRL7

    4. XM_017594956.3 → XP_017450445.1  protein MTSS 1 isoform X3

      UniProtKB/TrEMBL
      A6HRL7

    5. XM_063263853.1 → XP_063119923.1  protein MTSS 1 isoform X13

      UniProtKB/TrEMBL
      A6HRL7

    6. XM_063263848.1 → XP_063119918.1  protein MTSS 1 isoform X7

      UniProtKB/TrEMBL
      A6HRL7

    7. XM_063263847.1 → XP_063119917.1  protein MTSS 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2D5, A6HRL7

    8. XM_017594957.3 → XP_017450446.1  protein MTSS 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFD6, A6HRL7
      Related
      ENSRNOP00000086949.1

    9. XM_017594954.3 → XP_017450443.1  protein MTSS 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AWT9, A6HRL7
      Related
      ENSRNOP00000093281.1

    10. XM_039079520.2 → XP_038935448.1  protein MTSS 1 isoform X1

      UniProtKB/TrEMBL
      A6HRL7
      Conserved Domains (4) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:335 → 737
      PHA03247; large tegument protein UL36; Provisional
      PTZ00441
      Location:620 → 768
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd22060
      Location:739 → 769
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    11. XM_039079525.2 → XP_038935453.1  protein MTSS 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AN35, A6HRL7
      Related
      ENSRNOP00000097050.1
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PTZ00441
      Location:540 → 688
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd22060
      Location:659 → 689
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    12. XM_063263850.1 → XP_063119920.1  protein MTSS 1 isoform X10

      UniProtKB/TrEMBL
      A6HRL8

    13. XM_063263851.1 → XP_063119921.1  protein MTSS 1 isoform X11

      UniProtKB/TrEMBL
      A6HRL8
    Nucleotide Protein Strain
    Heading Accession and Version

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