RAB13 RAB13, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB13provided by HGNC
Official Full Name: RAB13, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9762
See related: Ensembl:ENSG00000143545 MIM:602672; AllianceGenome:HGNC:9762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GIG4
Summary: This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in urinary bladder (RPKM 34.2), prostate (RPKM 33.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (153981650..153990708, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (153118913..153127907, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (153954126..153958815, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13.
Title: Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13.
Construction of Two Independent RAB Family-Based Scoring Systems Based on Machine Learning Algorithms and Definition of RAB13 as a Novel Therapeutic Target for Hepatocellular Carcinoma.
Title: Construction of Two Independent RAB Family-Based Scoring Systems Based on Machine Learning Algorithms and Definition of RAB13 as a Novel Therapeutic Target for Hepatocellular Carcinoma.
Identification of autophagic target RAB13 with small-molecule inhibitor in low-grade glioma via integrated multi-omics approaches coupled with virtual screening of traditional Chinese medicine databases.
Title: Identification of autophagic target RAB13 with small-molecule inhibitor in low-grade glioma via integrated multi-omics approaches coupled with virtual screening of traditional Chinese medicine databases.
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
Title: RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
GGA2 and RAB13 are important specificity determinants for integrin activity-dependent traffic.
Title: GGA2 and RAB13 promote activity-dependent β1-integrin recycling.
The deletion of RAB13 inhibited the proliferation and promoted the apoptosis in AGS and NCI-N87cells, the impairments of viability which was due to reduced amount of RAB13 anchoring the plasma membrane and attenuated cellular response to EGF treatment and the activation of downstream Akt/ERK/mTOR signaling pathways accordingly.
Title: RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer.
Rab13 activated the downstream AMPK and blocked mTOR signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
Title: Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells.
Inactive Rab13 appears to associate with vesicles via protein-protein interactions. Only following activation does Rab13 associate with the plasma membrane, presumably with insertion of the C-terminal prenyl group into the membrane.
Title: Rab13 Traffics on Vesicles Independent of Prenylation.
the role of Rab13 as a potent driver of cancer progression.
Title: Regulation of Cancer Cell Behavior by the Small GTPase Rab13.
Rab8A GTPase Ser(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin at Ser(65).
Title: Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79166 (e-PCR)
- UniSTS:85251

D8S2279 (e-PCR)
- UniSTS:473907

RH70905 (e-PCR)
- UniSTS:89041

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of Sertoli cell barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell leading edge	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in trans-Golgi network to recycling endosome transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in insulin-responsive compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-13

Names: RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001272038.2 → NP_001258967.1 ras-related protein Rab-13 isoform 2

See identical proteins and their annotated locations for NP_001258967.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a novel 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AK291580, AL358472, BC009227, CN396084

Consensus CDS

CCDS72921.1

UniProtKB/TrEMBL

A0A087WWB9

Related

ENSP00000480103.1, ENST00000614713.4

Conserved Domains (1) summary

cl38936
Location:1 → 91

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_002870.5 → NP_002861.1 ras-related protein Rab-13 isoform 1

See identical proteins and their annotated locations for NP_002861.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK291580, BC000799, BC094846

Consensus CDS

CCDS1058.1

UniProtKB/Swiss-Prot

A8K6B5, D3DV67, P51153, Q5U0A6, Q6GPG6, Q96GU4

UniProtKB/TrEMBL

Q504R6

Related

ENSP00000357564.3, ENST00000368575.5

Conserved Domains (1) summary

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RNA

NR_073553.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK291580, BC000799, BU188046

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

153981650..153990708 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001959.2 → XP_016857448.1 ras-related protein Rab-13 isoform X1

UniProtKB/TrEMBL

A0A087WWB9

Conserved Domains (1) summary

cl38936
Location:1 → 91

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases