U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 66098, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Chchd6provided by MGI
    Official Full Name
    coiled-coil-helix-coiled-coil-helix domain containing 6provided by MGI
    Primary source
    MGI:MGI:1913348
    See related
    Ensembl:ENSMUSG00000030086 AllianceGenome:MGI:1913348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micos25; 0710001P09Rik; 1700021B03Rik
    Summary
    Predicted to be involved in cellular response to DNA damage stimulus and cristae formation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 117.1), CNS E18 (RPKM 34.0) and 16 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Chchd6 in Genome Data Viewer
    Location:
    6 D1; 6 39.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (89360128..89572634, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (89383146..89595652, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930512J16 gene Neighboring gene STARR-seq mESC enhancer starr_16595 Neighboring gene STARR-seq mESC enhancer starr_16597 Neighboring gene predicted gene, 36735 Neighboring gene STARR-positive B cell enhancer ABC_E10391 Neighboring gene STARR-seq mESC enhancer starr_16599 Neighboring gene STARR-seq mESC enhancer starr_16600 Neighboring gene plexin A1 Neighboring gene predicted gene, 52910 Neighboring gene predicted gene, 46966 Neighboring gene STARR-seq mESC enhancer starr_16603 Neighboring gene predicted gene, 19896 Neighboring gene 40S ribosomal protein S17 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Shang Y, et al. Acta Neuropathol, 2022 Nov. PMID 36104602, Free PMC Article
    2. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
      Title: A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    MICOS complex subunit Mic25
    Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167736.1 → NP_001161208.1  MICOS complex subunit Mic25 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK015314, BQ177996, BY278681
      Consensus CDS
      CCDS51846.1
      UniProtKB/TrEMBL
      E9Q4M4, Q9DA45
      Related
      ENSMUSP00000109179.4, ENSMUST00000113550.6
      Conserved Domains (2) summary
      pfam05300
      Location:17 → 199
      DUF737; Protein of unknown function (DUF737)
      pfam06747
      Location:207 → 240
      CHCH; CHCH domain

    2. NM_025351.3 → NP_079627.3  MICOS complex subunit Mic25 isoform 1

      See identical proteins and their annotated locations for NP_079627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK015314, BY278681
      Consensus CDS
      CCDS39557.1
      UniProtKB/Swiss-Prot
      Q3UNQ1, Q91VN4, Q9D5I5, Q9DAM8
      UniProtKB/TrEMBL
      Q9DA45
      Related
      ENSMUSP00000032172.9, ENSMUST00000032172.14
      Conserved Domains (2) summary
      pfam05300
      Location:17 → 227
      DUF737; Protein of unknown function (DUF737)
      pfam06747
      Location:235 → 268
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      89360128..89572634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VN4.2 GenPept UniProtKB/Swiss-Prot:Q91VN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous