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    Asb6 ankyrin repeat and SOCS box-containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 72323, updated on 8-May-2024

    Summary

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    Official Symbol
    Asb6provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 6provided by MGI
    Primary source
    MGI:MGI:1919573
    See related
    Ensembl:ENSMUSG00000039483 AllianceGenome:MGI:1919573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510004M11Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in limb and limb mesenchyme. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.4), adrenal adult (RPKM 25.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb6 in Genome Data Viewer
    Location:
    2 B; 2 21.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30713109..30718312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30823097..30828300, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001O22 gene Neighboring gene predicted gene, 54110 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10091 Neighboring gene paired related homeobox 2 Neighboring gene prostaglandin E synthase Neighboring gene predicted gene, 52550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. Wilcox A, et al. J Biol Chem, 2004 Sep 10. PMID 15231829
    2. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 6
    Names
    ASB-6
    ankyrin repeat and SOCS box-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133346.2 → NP_579924.1  ankyrin repeat and SOCS box protein 6

      See identical proteins and their annotated locations for NP_579924.1

      Status: VALIDATED

      Source sequence(s)
      AK049312, BY336511, CD776641
      Consensus CDS
      CCDS38096.1
      UniProtKB/Swiss-Prot
      Q8VEC6, Q91ZU1
      UniProtKB/TrEMBL
      Q6BCN6
      Related
      ENSMUSP00000043462.4, ENSMUST00000041726.4
      Conserved Domains (4) summary
      cd00204
      Location:102 → 212
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:368 → 411
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      pfam12796
      Location:71 → 166
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:103 → 131
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30713109..30718312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZU1.1 GenPept UniProtKB/Swiss-Prot:Q91ZU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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