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    macc1 MET transcriptional regulator MACC1 [ Danio rerio (zebrafish) ]

    Gene ID: 558777, updated on 27-Mar-2024

    Summary

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    Official Symbol
    macc1provided by ZNC
    Official Full Name
    MET transcriptional regulator MACC1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091006-3
    See related
    Ensembl:ENSDARG00000040717 AllianceGenome:ZFIN:ZDB-GENE-091006-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within embryonic cranial skeleton morphogenesis. Predicted to be active in cytoplasm. Is expressed in eye; midbrain hindbrain boundary; otic vesicle; stomodeum; and telencephalon. Orthologous to human MACC1 (MET transcriptional regulator MACC1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See macc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (19637445..19644458)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (19831626..19838639)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 5 Neighboring gene uncharacterized LOC108179597 Neighboring gene transmembrane protein 196b Neighboring gene twist family bHLH transcription factor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metastasis-associated in colon cancer protein 1
    Names
    metastasis associated in colon cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199766.1 → NP_001186695.1  metastasis-associated in colon cancer protein 1

      Status: VALIDATED

      Source sequence(s)
      BX005389
      UniProtKB/TrEMBL
      A0A8M1NXI5, E7FG38
      Related
      ENSDARP00000114832.1, ENSDART00000135359.2
      Conserved Domains (4) summary
      cd01670
      Location:747 → 822
      Death; Death Domain: a protein-protein interaction domain
      cl02517
      Location:220 → 261
      ZU5; ZU5 domain
      cl14633
      Location:660 → 741
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:557 → 621
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      19637445..19644458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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