brf1a BRF1 RNA polymerase III transcription initiation factor subunit a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: brf1aprovided by ZNC
Official Full Name: BRF1 RNA polymerase III transcription initiation factor subunit aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6334
See related: Ensembl:ENSDARG00000017835 AllianceGenome:ZFIN:ZDB-GENE-030131-6334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: brf1; zgc:55543; wu:fi47f03
Summary: Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within neutrophil differentiation. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Is expressed in several structures, including head; midbrain; notochord; pectoral fin musculature; and polster. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33368434..33448645)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33238035..33318195)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc21e08.y1 (e-PCR)
- UniSTS:193053

fc09a10.x1 (e-PCR)
- UniSTS:192372

fi66e01.y1 (e-PCR)
- UniSTS:197820

fi47f03.x1 (e-PCR)
- UniSTS:197604

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase III general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: BRF1 RNA polymerase III transcription initiation factor subunit a; BRF1, RNA polymerase III transcription initiation factor a

Names: BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199898.1 → NP_956192.1 BRF1 RNA polymerase III transcription initiation factor subunit a

See identical proteins and their annotated locations for NP_956192.1

Status: PROVISIONAL

Source sequence(s)

BC046877

UniProtKB/TrEMBL

Q802Z8

Related

ENSDARP00000029653.6, ENSDART00000033848.9

Conserved Domains (5) summary

COG1405
Location:1 → 277

SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

cd00043
Location:83 → 156

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

pfam07741
Location:439 → 531

BRF1; Brf1-like TBP-binding domain

pfam08271
Location:3 → 41

TF_Zn_Ribbon; TFIIB zinc-binding

cl00050
Location:185 → 258

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...