myb v-myb avian myeloblastosis viral oncogene homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mybprovided by ZNC
Official Full Name: v-myb avian myeloblastosis viral oncogene homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991110-14
See related: Ensembl:ENSDARG00000053666 AllianceGenome:ZFIN:ZDB-GENE-991110-14
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cmyb; c-myb
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including definitive hemopoiesis; hematopoietic stem cell migration; and regulation of neutrophil differentiation. Is active in chromatin. Is expressed in several structures, including head; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (31815423..31830043)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (31888892..31903512)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model.
Title: c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model.
The interaction of Pu.1 and cMyb in zebrafish neutrophil development.
Title: The interaction of Pu.1 and cMyb in zebrafish neutrophil development.
Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb.
Title: Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb.
The adult wave of microglia originates from cmyb-dependent hematopoietic stem cells.
Title: Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish.
Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.
Title: Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.
studies show that merestinib effectively blocks eIF4E phosphorylation in AML cells and suppresses primitive leukemic progenitors from AML patients in vitro and in an AML xenograft model in vivo.
Title: c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish.
cMyb plays a hitherto unidentified role in dictating physiologic HSPC migration by modulating Sdf1a signaling.
Title: cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis.
show that knockdown of miR-126 results in increased c-Myb levels and promotes erythropoiesis at the expense of thrombopoiesis in vivo
Title: Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
Results suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution.
Title: Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved.
expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM, and provide the means to further dissect HSC generation and
Title: CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

myb (e-PCR), detects polymorphism
- UniSTS:238203

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neutrophil differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: transcriptional activator Myb

Names: transcription factor cmyb

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309822.1 → NP_001296751.1 transcriptional activator Myb isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BX927365, CT573377

UniProtKB/TrEMBL

A0A8M1P6R3, F1QP24

Related

ENSDARP00000070211.5, ENSDART00000075730.7

Conserved Domains (4) summary

smart00717
Location:92 → 140

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:92 → 138

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:259 → 303

LMSTEN; LMSTEN motif

pfam09316
Location:417 → 560

Cmyb_C; C-myb, C-terminal
NM_131266.2 → NP_571341.2 transcriptional activator Myb isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

BX927365, CT573377

UniProtKB/TrEMBL

A0A8M1PBN3, F1QP25

Related

ENSDARP00000070207.4, ENSDART00000075726.5

Conserved Domains (4) summary

smart00717
Location:92 → 140

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:92 → 138

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:259 → 303

LMSTEN; LMSTEN motif

pfam09316
Location:370 → 509

Cmyb_C; C-myb, C-terminal