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    Tmem176a transmembrane protein 176A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297077, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tmem176aprovided by RGD
    Official Full Name
    transmembrane protein 176Aprovided by RGD
    Primary source
    RGD:1310725
    See related
    Ensembl:ENSRNOG00000023708 AllianceGenome:RGD:1310725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310725; 0610011i04rik
    Summary
    Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be integral component of membrane. Orthologous to human TMEM176A (transmembrane protein 176A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 543.8), Spleen (RPKM 456.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem176a in Genome Data Viewer
    Location:
    4q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79101946..79109499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77774940..77778620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78458735..78462415)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 5 Neighboring gene transmembrane protein 176B Neighboring gene amine oxidase, copper containing 1 Neighboring gene DAB2 interacting protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. Condamine T, et al. J Leukoc Biol, 2010 Sep. PMID 20501748
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112703

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 176A
    Names
    hepatocellular carcinoma-associated antigen 112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039008.1 → NP_001034097.1  transmembrane protein 176A

      See identical proteins and their annotated locations for NP_001034097.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098714
      UniProtKB/Swiss-Prot
      Q4G068
      UniProtKB/TrEMBL
      A6K0J1
      Related
      ENSRNOP00000048649.2, ENSRNOT00000049891.5
      Conserved Domains (1) summary
      pfam04103
      Location:63 → 223
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      79101946..79109499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285768.1 → XP_063141838.1  transmembrane protein 176A isoform X1

    2. XM_063285769.1 → XP_063141839.1  transmembrane protein 176A isoform X2

      UniProtKB/Swiss-Prot
      Q4G068
      UniProtKB/TrEMBL
      A6K0J1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G068.1 GenPept UniProtKB/Swiss-Prot:Q4G068

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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