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    MED21 Mediator complex subunit 21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354977, updated on 10-May-2024

    Summary

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    Official Symbol
    MED21provided by FlyBase
    Official Full Name
    Mediator complex subunit 21provided by FlyBase
    Primary source
    FLYBASE:FBgn0040020
    Locus tag
    Dmel_CG17397
    See related
    AllianceGenome:FB:FBgn0040020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17397; CG40364; Dmel\CG17397; dSRB7; dTRAP19; med21; Med21; p18; Trap19
    Summary
    Enables transcription coregulator activity. Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See MED21 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25114924..25115946, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (600380..601402, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46483 Neighboring gene NADH dehydrogenase (ubiquinone) AGGG subunit Neighboring gene SET domain containing 1 Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Park JM, et al. Mol Cell Biol, 2003 Feb. PMID 12556495, Free PMC Article
    2. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Pek JW, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21730191, Free PMC Article
    3. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356
    4. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article
    5. Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males. Koya SK, et al. PLoS One, 2015. PMID 26468879, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 21
    Names
    CG17397-PA
    CG17397-PB
    MED21-PA
    MED21-PB
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      25114924..25115946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015224.3 → NP_001015224.1  mediator complex subunit 21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y534, Q9W5P1
      UniProtKB/TrEMBL
      A0A1B2AKZ9
      Conserved Domains (1) summary
      pfam11221
      Location:1 → 128
      Med21; Subunit 21 of Mediator complex

    2. NM_001015223.3 → NP_001015223.1  mediator complex subunit 21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015223.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y534, Q9W5P1
      UniProtKB/TrEMBL
      A0A1B2AKZ9
      Conserved Domains (1) summary
      pfam11221
      Location:1 → 128
      Med21; Subunit 21 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5P1.1 Q9W5P1

    Gene LinkOut

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