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    CG1674 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43780, updated on 10-May-2024

    Summary

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    Official Symbol
    CG1674provided by FlyBase
    Primary source
    FLYBASE:FBgn0039897
    Locus tag
    Dmel_CG1674
    See related
    AllianceGenome:FB:FBgn0039897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1674
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in positive regulation of actin filament bundle assembly. Located in Z disc. Is expressed in adult head; adult heart; embryonic/larval muscle system; and spermatozoon. Orthologous to human SYNPO (synaptopodin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG1674 in Genome Data Viewer
    Location:
    102B1-102B1; 4-0 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (230730..245903)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (251356..266529)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene antisense RNA:CR46065 Neighboring gene yellow-h Neighboring gene defective proboscis extension response 7 Neighboring gene Rho GTPase activating protein at 102A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila CG1674 gene encodes a synaptopodin 2-like related protein that localizes to the Z-disc and is required for normal flight muscle development and function. Czajkowski ER, et al. Dev Dyn, 2021 Jan. PMID 32893414, Free PMC Article
    2. An undergraduate laboratory class using CRISPR/Cas9 technology to mutate drosophila genes. Adame V, et al. Biochem Mol Biol Educ, 2016 May 6. PMID 27009801, Free PMC Article
    3. The developmental proteome of Drosophila melanogaster. Casas-Vila N, et al. Genome Res, 2017 Jul. PMID 28381612, Free PMC Article
    4. High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis. Sridharan V, et al. PLoS One, 2016. PMID 26942929, Free PMC Article
    5. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Podemski L, et al. Chromosoma, 2004 Jun. PMID 15185094

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila CG1674 gene encodes a synaptopodin 2-like related protein that localizes to the Z-disc and is required for normal flight muscle development and function.
      Title: The Drosophila CG1674 gene encodes a synaptopodin 2-like related protein that localizes to the Z-disc and is required for normal flight muscle development and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 233400-233839 mobile_element_type = transposon:INE-1{}4865
    • Loc: 235253-235436 mobile_element_type = transposon:INE-1{}5339
    • Loc: 235454-235928 mobile_element_type = transposon:INE-1{}5341

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1674-PB
    CG1674-PD
    CG1674-PE
    CG1674-PF
    CG1674-PH
    CG1674-PI
    CG1674-PJ
    CG1674-PK
    CG1674-PL
    CG1674-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      230730..245903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143656.2 → NP_651913.1  uncharacterized protein Dmel_CG1674, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMB9, Q8SXK8
      Related
      FBpp0088185
      Conserved Domains (1) summary
      COG5271
      Location:6 → 380
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. NM_001169351.2 → NP_001162822.1  uncharacterized protein Dmel_CG1674, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C1
      Conserved Domains (1) summary
      COG5271
      Location:6 → 353
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    3. NM_001272120.1 → NP_001259049.1  uncharacterized protein Dmel_CG1674, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MLJ3
      Conserved Domains (1) summary
      COG5271
      Location:6 → 353
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    4. NM_166746.3 → NP_726553.2  uncharacterized protein Dmel_CG1674, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726553.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMB8, Q8SXK8

    5. NM_166747.3 → NP_726554.2  uncharacterized protein Dmel_CG1674, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726554.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C1
      Conserved Domains (1) summary
      COG5271
      Location:6 → 353
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    6. NM_001258485.2 → NP_001245414.1  uncharacterized protein Dmel_CG1674, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQE7, H9XVM9

    7. NM_001258484.2 → NP_001245413.1  uncharacterized protein Dmel_CG1674, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQE7, H9XVM8

    8. NM_001169352.2 → NP_001162823.1  uncharacterized protein Dmel_CG1674, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RKY9

    9. NM_205866.3 → NP_995588.1  uncharacterized protein Dmel_CG1674, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGF3

    10. NM_001169350.2 → NP_001162821.1  uncharacterized protein Dmel_CG1674, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C1
      Conserved Domains (1) summary
      COG5271
      Location:6 → 353
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVM8 H9XVM8
    H9XVM9 H9XVM9
    L0MLJ3 L0MLJ3
    Q1RKY9 Q1RKY9
    Q8IGF3 Q8IGF3
    Q8IMB8 Q8IMB8
    Q8IMB9 Q8IMB9
    Q8SXK8 Q8SXK8
    Q9V4C1 Q9V4C1

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