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    Sf3b1 Splicing factor 3b subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33235, updated on 10-May-2024

    Summary

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    Official Symbol
    Sf3b1provided by FlyBase
    Official Full Name
    Splicing factor 3b subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031266
    Locus tag
    Dmel_CG2807
    See related
    AllianceGenome:FB:FBgn0031266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-21Cd; CG2807; Dmel\CG2807; SF3B; SF3B1
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in spliceosomal complex assembly. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Sf3b1 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (568340..572907)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (568340..572907)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene uncharacterized protein Neighboring gene Notchless Neighboring gene Inositol phosphate kinase 2 Neighboring gene coiled Neighboring gene Prothoracicotropic hormone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila. Zhang B, et al. PLoS Genet, 2021 Nov. PMID 34723968, Free PMC Article
    2. A PROTAC targets splicing factor 3B1. Gama-Brambila RA, et al. Cell Chem Biol, 2021 Nov 18. PMID 34048672
    3. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Valakh V, et al. Dev Biol, 2012 Jun 15. PMID 22542760, Free PMC Article
    4. Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model. Pons M, et al. Hum Mol Genet, 2017 Sep 1. PMID 28854702
    5. Drosophila as a Potential Model for Ocular Tumors. Bennett D, et al. Ocul Oncol Pathol, 2015 Apr. PMID 27172095, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    splicing factor 3b subunit 1
    Names
    CG2807-PA
    CG2807-PB
    Sf3b1-PA
    Sf3b1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      568340..572907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272908.1 → NP_001259837.1  splicing factor 3b subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5E9, Q9VPR5
      Conserved Domains (5) summary
      COG5181
      Location:483 → 1340
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      cd00020
      Location:1016 → 1117
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08920
      Location:340 → 477
      SF3b1; Splicing factor 3B subunit 1
      pfam13513
      Location:947 → 994
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:886 → 910
      HEAT; HEAT repeat [structural motif]

    2. NM_134690.4 → NP_608534.2  splicing factor 3b subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608534.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5E9, Q9VPR5
      Related
      FBpp0077728
      Conserved Domains (5) summary
      COG5181
      Location:483 → 1340
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      cd00020
      Location:1016 → 1117
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08920
      Location:340 → 477
      SF3b1; Splicing factor 3B subunit 1
      pfam13513
      Location:947 → 994
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:886 → 910
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPR5 Q9VPR5

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