Skp1 S-phase kinase-associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Skp1provided by RGD
Official Full Name: S-phase kinase-associated protein 1provided by RGD
Primary source: RGD:1359648
See related: Ensembl:ENSRNOG00000005828 AllianceGenome:RGD:1359648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Skp1a
Summary: Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin protein ligase activity; and protein ubiquitination. Predicted to act upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Predicted to be located in centrosome and cytosol. Predicted to be part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2525.7), Adrenal (RPKM 1819.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (36898670..36917828)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (36401987..36417066)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (37594578..37609498)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study indicated that cyclin A, cyclin D, Cdk2, Cdk4, and p21 are involved in microglial proliferation in the transected facial nucleus.
Title: Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137096 (e-PCR)
- UniSTS:219184

Tceb1l-rs1 (e-PCR), detects polymorphism
- UniSTS:144553

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables F-box domain binding	IEA Inferred from Electronic Annotation more info
enables F-box domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin ligase complex scaffold activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase complex scaffold activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in nucleus	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul7-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul7-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul7-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: S-phase kinase-associated protein 1

Names: RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1A; cyclin A/CDK2-associated p19; cyclin-A/CDK2-associated protein p19; organ of Corti protein 2; p19A; p19skp1

NP_001007609.1

EC 3.1.1.3

XP_038941314.1

EC 3.1.1.3

XP_063124657.1

EC 3.1.1.3

XP_063124658.1

EC 3.1.1.3

XP_063124659.1

EC 3.1.1.3

XP_063124660.1

EC 3.1.1.3

XP_063124661.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007608.2 → NP_001007609.1 S-phase kinase-associated protein 1

See identical proteins and their annotated locations for NP_001007609.1

Status: PROVISIONAL

Source sequence(s)

BC058152

UniProtKB/Swiss-Prot

Q6PEC4

UniProtKB/TrEMBL

A0A8L2Q2U6, A6HEA2

Related

ENSRNOP00000007676.6, ENSRNOT00000007676.8

Conserved Domains (2) summary

cd18322
Location:3 → 127

BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins

pfam01466
Location:113 → 160

Skp1; Skp1 family, dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

36898670..36917828

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268589.1 → XP_063124659.1 S-phase kinase-associated protein 1 isoform X2

UniProtKB/TrEMBL

A0A8L2Q2U6
XM_063268590.1 → XP_063124660.1 S-phase kinase-associated protein 1 isoform X4

UniProtKB/Swiss-Prot

Q6PEC4

UniProtKB/TrEMBL

A0A8L2Q2U6, A6HEA2
XM_063268591.1 → XP_063124661.1 S-phase kinase-associated protein 1 isoform X4

UniProtKB/Swiss-Prot

Q6PEC4

UniProtKB/TrEMBL

A0A8L2Q2U6, A6HEA2
XM_063268588.1 → XP_063124658.1 S-phase kinase-associated protein 1 isoform X2

UniProtKB/TrEMBL

A0A8L2Q2U6
XM_039085386.2 → XP_038941314.1 S-phase kinase-associated protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K4X8, A0A8L2Q2U6

Related

ENSRNOP00000073214.1

Conserved Domains (2) summary

cd18322
Location:5 → 129

BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins

pfam01466
Location:115 → 162

Skp1; Skp1 family, dimerization domain
XM_063268587.1 → XP_063124657.1 S-phase kinase-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2Q2U6