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    Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309053, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Relchprovided by RGD
    Official Full Name
    RAB11 binding and LisH domain, coiled-coil and HEAT repeat containingprovided by RGD
    Primary source
    RGD:1307235
    See related
    Ensembl:ENSRNOG00000015508 AllianceGenome:RGD:1307235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307235
    Summary
    Predicted to be involved in intracellular cholesterol transport. Predicted to be located in recycling endosome and trans-Golgi network. Orthologous to human RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 175.3), Thymus (RPKM 171.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Relch in Genome Data Viewer
    Location:
    13p11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (22321495..22417371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21806972..21902807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25656983..25752792)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene transfer RNA histidin (anticodon AUG) 1 Neighboring gene TNF receptor superfamily member 11A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, et al. J Cell Biol, 2018 May 7. PMID 29514919, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAB11-binding protein RELCH

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134546.1 → NP_001128018.1  RAB11-binding protein RELCH

      See identical proteins and their annotated locations for NP_001128018.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474000
      UniProtKB/TrEMBL
      A0A8I6AUX6, A6JST7, D3ZJ01
      Related
      ENSRNOP00000020892.4, ENSRNOT00000020892.5
      Conserved Domains (1) summary
      sd00044
      Location:521 → 553
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      22321495..22417371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090853.2 → XP_038946781.1  RAB11-binding protein RELCH isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRA1, A0A8I6AUX6
      Related
      ENSRNOP00000080664.1
      Conserved Domains (1) summary
      sd00044
      Location:650 → 679
      HEAT; HEAT repeat [structural motif]

    2. XM_039090854.2 → XP_038946782.1  RAB11-binding protein RELCH isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUX6
      Conserved Domains (1) summary
      sd00044
      Location:650 → 679
      HEAT; HEAT repeat [structural motif]

    3. XM_039090855.2 → XP_038946783.1  RAB11-binding protein RELCH isoform X3

      UniProtKB/TrEMBL
      A0A8I6AUX6
      Conserved Domains (1) summary
      sd00044
      Location:650 → 679
      HEAT; HEAT repeat [structural motif]

    4. XM_039090856.2 → XP_038946784.1  RAB11-binding protein RELCH isoform X4

      UniProtKB/TrEMBL
      A0A8I6AUX6
      Conserved Domains (1) summary
      sd00044
      Location:650 → 679
      HEAT; HEAT repeat [structural motif]

    5. XM_039090857.2 → XP_038946785.1  RAB11-binding protein RELCH isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARP7, A0A8I6AUX6
      Related
      ENSRNOP00000096002.1
      Conserved Domains (1) summary
      sd00044
      Location:521 → 553
      HEAT; HEAT repeat [structural motif]

    6. XM_063272420.1 → XP_063128490.1  RAB11-binding protein RELCH isoform X6

      UniProtKB/TrEMBL
      A0A8I6AUX6

    7. XM_039090859.2 → XP_038946787.1  RAB11-binding protein RELCH isoform X7

      UniProtKB/TrEMBL
      A0A8I6AUX6
      Conserved Domains (1) summary
      sd00044
      Location:521 → 553
      HEAT; HEAT repeat [structural motif]

    8. XM_039090860.2 → XP_038946788.1  RAB11-binding protein RELCH isoform X8

      UniProtKB/TrEMBL
      A0A8I6AUX6
      Conserved Domains (1) summary
      sd00044
      Location:626 → 655
      HEAT; HEAT repeat [structural motif]

    9. XM_039090861.2 → XP_038946789.1  RAB11-binding protein RELCH isoform X9

      UniProtKB/TrEMBL
      A0A8I6AUX6, A0A8I6GIS7
      Related
      ENSRNOP00000090311.1
      Conserved Domains (1) summary
      sd00044
      Location:497 → 529
      HEAT; HEAT repeat [structural motif]

    10. XM_039090864.2 → XP_038946792.1  RAB11-binding protein RELCH isoform X11

      Conserved Domains (2) summary
      smart00667
      Location:255 → 287
      LisH; Lissencephaly type-1-like homology motif
      sd00044
      Location:575 → 597
      HEAT; HEAT repeat [structural motif]

    11. XM_039090862.2 → XP_038946790.1  RAB11-binding protein RELCH isoform X10

      Conserved Domains (1) summary
      sd00044
      Location:264 → 293
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_005492251.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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