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    Kcnt2 potassium channel, subfamily T, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 240776, updated on 12-May-2024

    Summary

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    Official Symbol
    Kcnt2provided by MGI
    Official Full Name
    potassium channel, subfamily T, member 2provided by MGI
    Primary source
    MGI:MGI:3036273
    See related
    Ensembl:ENSMUSG00000052726 AllianceGenome:MGI:3036273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slick; E330038N15Rik
    Summary
    Predicted to enable chloride-activated potassium channel activity; intracellular sodium activated potassium channel activity; and outward rectifier potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to act upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in forebrain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 2.5), frontal lobe adult (RPKM 1.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnt2 in Genome Data Viewer
    Location:
    1 F; 1 61.62 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (140173373..140541783)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (140245657..140614045)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26048 Neighboring gene STARR-seq mESC enhancer starr_02496 Neighboring gene STARR-seq mESC enhancer starr_02497 Neighboring gene complement component factor h Neighboring gene STARR-seq mESC enhancer starr_02498 Neighboring gene STARR-seq mESC enhancer starr_02500 Neighboring gene RIKEN cDNA 4930590L20 gene Neighboring gene STARR-seq mESC enhancer starr_02501 Neighboring gene STARR-seq mESC enhancer starr_02502 Neighboring gene STARR-seq mESC enhancer starr_02503 Neighboring gene STARR-seq mESC enhancer starr_02505 Neighboring gene STARR-seq mESC enhancer starr_02507 Neighboring gene STARR-seq mESC enhancer starr_02508 Neighboring gene STARR-seq mESC enhancer starr_02509 Neighboring gene glutathione S-transferase, mu 4 pseudogene Neighboring gene glutathione S-transferase, mu 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Liu B, et al. Nat Commun, 2020 Aug 14. PMID 32796851, Free PMC Article
    2. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. Reijntjes DOJ, et al. Sci Rep, 2019 Feb 22. PMID 30796290, Free PMC Article
    3. Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Wojtovich AP, et al. Anesthesiology, 2016 May. PMID 26845140, Free PMC Article
    4. Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain. Rizzi S, et al. J Comp Neurol, 2016 Jul 1. PMID 26587966, Free PMC Article
    5. Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. Yang B, et al. J Neurosci, 2007 Mar 7. PMID 17344399, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
      Title: An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
    2. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
      Title: Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
    3. This study showed that the Intense Slick channel immunoreactivity was observed in processes, varicosities, and neuronal cell bodies of the olfactory bulb, granular zones of cortical regions, hippocampus, amygdala, lateral septal nuclei, certain hypothalamic and midbrain nuclei, and several regions of the brainstem.
      Title: Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.
    4. Slick (Slo2.1) is required for both volatile anesthetics-stimulated K flux and for the anesthetic preconditioning-induced cardioprotection
      Title: Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.
    5. Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.
      Title: Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily T member 2
    Names
    sodium- and chloride-activated ATP-sensitive potassium channel subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081027.3 → NP_001074496.2  potassium channel subfamily T member 2

      Status: VALIDATED

      Source sequence(s)
      AC120400, AC156607, AC156989
      Consensus CDS
      CCDS48389.1
      UniProtKB/TrEMBL
      D3Z649
      Related
      ENSMUSP00000113333.2, ENSMUST00000120796.8
      Conserved Domains (2) summary
      pfam03493
      Location:431 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:226 → 272
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      140173373..140541783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247999.3 → XP_011246301.1  potassium channel subfamily T member 2 isoform X14

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 558
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    2. XM_017320510.2 → XP_017175999.1  potassium channel subfamily T member 2 isoform X9

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 558
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    3. XM_017320506.2 → XP_017175995.1  potassium channel subfamily T member 2 isoform X1

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 558
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    4. XM_017320508.2 → XP_017175997.1  potassium channel subfamily T member 2 isoform X5

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 558
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    5. XM_006529562.4 → XP_006529625.1  potassium channel subfamily T member 2 isoform X3

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    6. XM_011247997.3 → XP_011246299.1  potassium channel subfamily T member 2 isoform X10

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel
      cl29357
      Location:456 → 496
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    7. XM_006529567.2 → XP_006529630.1  potassium channel subfamily T member 2 isoform X12

      Conserved Domains (2) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    8. XM_006529572.4 → XP_006529635.1  potassium channel subfamily T member 2 isoform X17

      Conserved Domains (2) summary
      pfam03493
      Location:431 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel

    9. XM_017320507.2 → XP_017175996.1  potassium channel subfamily T member 2 isoform X2

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 558
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    10. XM_017320509.2 → XP_017175998.1  potassium channel subfamily T member 2 isoform X6

      Conserved Domains (2) summary
      pfam03493
      Location:431 → 533
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel

    11. XM_006529565.4 → XP_006529628.1  potassium channel subfamily T member 2 isoform X8

      Conserved Domains (2) summary
      pfam03493
      Location:431 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel

    12. XM_030253999.2 → XP_030109859.1  potassium channel subfamily T member 2 isoform X4

      Conserved Domains (3) summary
      pfam00520
      Location:140 → 295
      Ion_trans; Ion transport protein
      pfam03493
      Location:456 → 551
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:242 → 297
      Ion_trans_2; Ion channel

    13. XM_011247996.4 → XP_011246298.1  potassium channel subfamily T member 2 isoform X7

      Conserved Domains (2) summary
      pfam03493
      Location:431 → 533
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel

    14. XM_011247998.4 → XP_011246300.1  potassium channel subfamily T member 2 isoform X13

      UniProtKB/TrEMBL
      D3Z592
      Related
      ENSMUSP00000113535.2, ENSMUST00000119786.8
      Conserved Domains (2) summary
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel
      cl29357
      Location:431 → 471
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    15. XM_006529566.5 → XP_006529629.1  potassium channel subfamily T member 2 isoform X11

      UniProtKB/TrEMBL
      D3YTU6
      Related
      ENSMUSP00000112887.2, ENSMUST00000120709.8
      Conserved Domains (2) summary
      pfam03493
      Location:431 → 526
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:205 → 272
      Ion_trans_2; Ion channel

    16. XM_036164770.1 → XP_036020663.1  potassium channel subfamily T member 2 isoform X16

      Conserved Domains (1) summary
      pfam03493
      Location:1 → 87
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    17. XM_017320512.2 → XP_017176001.1  potassium channel subfamily T member 2 isoform X15

      Conserved Domains (1) summary
      pfam03493
      Location:1 → 90
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    RNA

    1. XR_004942432.1 RNA Sequence

    2. XR_001784494.2 RNA Sequence

    3. XR_001784498.2 RNA Sequence

    4. XR_001784492.2 RNA Sequence

    5. XR_001784491.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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