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    Lrrc38 leucine rich repeat containing 38 [ Mus musculus (house mouse) ]

    Gene ID: 242735, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrrc38provided by MGI
    Official Full Name
    leucine rich repeat containing 38provided by MGI
    Primary source
    MGI:MGI:2442845
    See related
    Ensembl:ENSMUSG00000028584 AllianceGenome:MGI:2442845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230053A07Rik
    Summary
    Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC38 (leucine rich repeat containing 38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 1.6), mammary gland adult (RPKM 0.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc38 in Genome Data Viewer
    Location:
    4 E1; 4 77.55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143076242..143097602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143347076..143371032)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11964 Neighboring gene podoplanin Neighboring gene STARR-seq mESC enhancer starr_11968 Neighboring gene STARR-seq mESC enhancer starr_11971 Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene PRAME like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 38
    Names
    BK channel auxiliary gamma subunit LRRC38
    BK channel auxilliary gamma subunit LRRC38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162983.1 → NP_001156455.1  leucine-rich repeat-containing protein 38 precursor

      See identical proteins and their annotated locations for NP_001156455.1

      Status: VALIDATED

      Source sequence(s)
      AK045936, AK160116, AL611982, BC129963
      Consensus CDS
      CCDS51351.1
      UniProtKB/Swiss-Prot
      A2A8J4, A2VDH3, Q3TVH8, Q8BR15
      Related
      ENSMUSP00000053597.3, ENSMUST00000052458.3
      Conserved Domains (5) summary
      smart00013
      Location:31 → 62
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:49 → 190
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:42 → 64
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:133 → 191
      LRR_8; Leucine rich repeat
      cl15307
      Location:190 → 244
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      143076242..143097602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538855.5 → XP_006538918.1  leucine-rich repeat-containing protein 38 isoform X1

      See identical proteins and their annotated locations for XP_006538918.1

      Conserved Domains (3) summary
      smart00013
      Location:171 → 202
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:182 → 204
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:273 → 331
      LRR_8; Leucine rich repeat

    RNA

    1. XR_390747.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VDH3.2 GenPept UniProtKB/Swiss-Prot:A2VDH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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