Eif4g1 eukaryotic translation initiation factor 4, gamma 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4g1provided by MGI
Official Full Name: eukaryotic translation initiation factor 4, gamma 1provided by MGI
Primary source: MGI:MGI:2384784
See related: Ensembl:ENSMUSG00000045983 AllianceGenome:MGI:2384784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: eIF4GI; eIF-4G1; eIF-4G 1; E030015G23Rik; eIF-4-gamma 1
Summary: This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 72.7), limb E14.5 (RPKM 65.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 12.49 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (20491457..20511633)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (20672720..20692883)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.
Title: The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.
Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic beta-Cell Function.
Title: Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic β-Cell Function.
EIF4G microexon-deficient mice display social behavior and memory deficits.
Title: Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
The results reveal that OGT O-GlcNAc-modifies eIF4G1 at Ser-61 and that this modification is critical for eIF4G1 protein stability.
Title: eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase-deficient pancreatic β-cells contributes to hyperproinsulinemia in mice.
eIF4G1 expression was increased in prostate cancer and that increased eIF4G1 expression was associated with tumor progression and metastasis.
Title: Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
eIF4GI acts as a translational switch via reversible O-GlcNAcylation
Title: O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.
Title: Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Disruption of insulin receptor (IR) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor Eif4g1.
Title: Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
Data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1, in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K activation.
Title: MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
expression of 3e5 diminishes eIF4G interaction with eIF3 and causes abnormal gene expression at the translational level.
Title: Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742434 (e-PCR)
- UniSTS:209186

AI428301 (e-PCR)
- UniSTS:160547

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation factor activity, RNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in macromolecule biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA cap binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell periphery	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 4F complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4 gamma 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304432.2 → NP_001291361.1 eukaryotic translation initiation factor 4 gamma 1 isoform c

See identical proteins and their annotated locations for NP_001291361.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.

Source sequence(s)

AC087898

Consensus CDS

CCDS84213.1

UniProtKB/TrEMBL

A0A0J9YUS5

Related

ENSMUSP00000111123.2, ENSMUST00000115463.8

Conserved Domains (3) summary

cd11559
Location:1427 → 1556

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1228 → 1340

MA3; MA3 domain

pfam02854
Location:758 → 986

MIF4G; MIF4G domain
NM_001403460.1 → NP_001390389.1 eukaryotic translation initiation factor 4 gamma 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC087898

UniProtKB/TrEMBL

E9PVC5

Related

ENSMUSP00000111121.2, ENSMUST00000115461.8
NM_001403461.1 → NP_001390390.1 eukaryotic translation initiation factor 4 gamma 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC087898

UniProtKB/TrEMBL

E9PVC5
NM_001403462.1 → NP_001390391.1 eukaryotic translation initiation factor 4 gamma 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC087898

UniProtKB/TrEMBL

E9Q9E1

Related

ENSMUSP00000073506.6, ENSMUST00000073840.12
NM_001403463.1 → NP_001390392.1 eukaryotic translation initiation factor 4 gamma 1 isoform c

Status: VALIDATED

Source sequence(s)

AC087898
NM_001403464.1 → NP_001390393.1 eukaryotic translation initiation factor 4 gamma 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC087898
NM_001403465.1 → NP_001390394.1 eukaryotic translation initiation factor 4 gamma 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC087898
NM_001403466.1 → NP_001390395.1 eukaryotic translation initiation factor 4 gamma 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC087898

UniProtKB/TrEMBL

E9PVC6
NM_001403467.1 → NP_001390396.1 eukaryotic translation initiation factor 4 gamma 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC087898
NM_001403468.1 → NP_001390397.1 eukaryotic translation initiation factor 4 gamma 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC087898

Related

ENSMUST00000132320.8
NM_145941.4 → NP_666053.2 eukaryotic translation initiation factor 4 gamma 1 isoform a

See identical proteins and their annotated locations for NP_666053.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC087898

Consensus CDS

CCDS28055.1

UniProtKB/Swiss-Prot

Q6NZJ6, Q6NZN8, Q8BW99

UniProtKB/TrEMBL

A0A0J9YUS5

Related

ENSMUSP00000047678.8, ENSMUST00000044783.14

Conserved Domains (5) summary

cd11559
Location:1441 → 1570

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:4 → 463

PHA03247; large tegument protein UL36; Provisional

TIGR00600
Location:373 → 612

rad2; DNA excision repair protein (rad2)

pfam02847
Location:1242 → 1354

MA3; MA3 domain

pfam02854
Location:765 → 993

MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

20491457..20511633

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521935.2 → XP_006521998.1 eukaryotic translation initiation factor 4 gamma 1 isoform X1

See identical proteins and their annotated locations for XP_006521998.1

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1442 → 1571

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:4 → 463

PHA03247; large tegument protein UL36; Provisional

TIGR00600
Location:373 → 612

rad2; DNA excision repair protein (rad2)

pfam02847
Location:1243 → 1355

MA3; MA3 domain

pfam02854
Location:766 → 994

MIF4G; MIF4G domain
XM_006521937.2 → XP_006522000.1 eukaryotic translation initiation factor 4 gamma 1 isoform X2

See identical proteins and their annotated locations for XP_006522000.1

UniProtKB/Swiss-Prot

Q6NZJ6, Q6NZN8, Q8BW99

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1441 → 1570

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:4 → 463

PHA03247; large tegument protein UL36; Provisional

TIGR00600
Location:373 → 612

rad2; DNA excision repair protein (rad2)

pfam02847
Location:1242 → 1354

MA3; MA3 domain

pfam02854
Location:765 → 993

MIF4G; MIF4G domain
XM_011245861.2 → XP_011244163.1 eukaryotic translation initiation factor 4 gamma 1 isoform X5

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1432 → 1561

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:7 → 560

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1233 → 1345

MA3; MA3 domain

pfam02854
Location:756 → 984

MIF4G; MIF4G domain
XM_030249023.2 → XP_030104883.1 eukaryotic translation initiation factor 4 gamma 1 isoform X6

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1431 → 1560

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:7 → 560

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1232 → 1344

MA3; MA3 domain

pfam02854
Location:755 → 983

MIF4G; MIF4G domain
XM_006521940.5 → XP_006522003.1 eukaryotic translation initiation factor 4 gamma 1 isoform X4

UniProtKB/TrEMBL

A0A0J9YUS5, E9Q9E1

Conserved Domains (5) summary

cd11559
Location:1434 → 1563

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:4 → 456

PHA03247; large tegument protein UL36; Provisional

TIGR00600
Location:366 → 605

rad2; DNA excision repair protein (rad2)

pfam02847
Location:1235 → 1347

MA3; MA3 domain

pfam02854
Location:758 → 986

MIF4G; MIF4G domain
XM_006521944.4 → XP_006522007.1 eukaryotic translation initiation factor 4 gamma 1 isoform X10

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1395 → 1524

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:2 → 523

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:156 → 415

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02847
Location:1196 → 1308

MA3; MA3 domain

pfam02854
Location:719 → 947

MIF4G; MIF4G domain
XM_006521943.2 → XP_006522006.1 eukaryotic translation initiation factor 4 gamma 1 isoform X9

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1402 → 1531

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:20 → 530

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1203 → 1315

MA3; MA3 domain

pfam02854
Location:726 → 954

MIF4G; MIF4G domain
XM_036159852.1 → XP_036015745.1 eukaryotic translation initiation factor 4 gamma 1 isoform X11

UniProtKB/TrEMBL

A0A0J9YUS5, E9PVC6

Related

ENSMUSP00000111117.2, ENSMUST00000115457.8

Conserved Domains (5) summary

cd11559
Location:1394 → 1523

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:2 → 523

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:156 → 415

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02847
Location:1195 → 1307

MA3; MA3 domain

pfam02854
Location:718 → 946

MIF4G; MIF4G domain
XM_036159855.1 → XP_036015748.1 eukaryotic translation initiation factor 4 gamma 1 isoform X14

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1384 → 1513

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

TIGR00600
Location:316 → 555

rad2; DNA excision repair protein (rad2)

pfam05109
Location:146 → 405

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02847
Location:1185 → 1297

MA3; MA3 domain

pfam02854
Location:708 → 936

MIF4G; MIF4G domain
XM_006521936.3 → XP_006521999.1 eukaryotic translation initiation factor 4 gamma 1 isoform X1

See identical proteins and their annotated locations for XP_006521999.1

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1442 → 1571

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:4 → 463

PHA03247; large tegument protein UL36; Provisional

TIGR00600
Location:373 → 612

rad2; DNA excision repair protein (rad2)

pfam02847
Location:1243 → 1355

MA3; MA3 domain

pfam02854
Location:766 → 994

MIF4G; MIF4G domain
XM_030249025.2 → XP_030104885.1 eukaryotic translation initiation factor 4 gamma 1 isoform X9

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1402 → 1531

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:20 → 530

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1203 → 1315

MA3; MA3 domain

pfam02854
Location:726 → 954

MIF4G; MIF4G domain
XM_006521945.2 → XP_006522008.1 eukaryotic translation initiation factor 4 gamma 1 isoform X12

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1392 → 1521

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:73 → 520

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1193 → 1305

MA3; MA3 domain

pfam02854
Location:716 → 944

MIF4G; MIF4G domain
XM_030249026.2 → XP_030104886.1 eukaryotic translation initiation factor 4 gamma 1 isoform X10

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (5) summary

cd11559
Location:1395 → 1524

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:2 → 523

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:156 → 415

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02847
Location:1196 → 1308

MA3; MA3 domain

pfam02854
Location:719 → 947

MIF4G; MIF4G domain
XM_036159856.1 → XP_036015749.1 eukaryotic translation initiation factor 4 gamma 1 isoform X16

UniProtKB/TrEMBL

A0A0J9YUS5

Related

ENSMUSP00000144320.2, ENSMUST00000143939.8

Conserved Domains (4) summary

cd11559
Location:1347 → 1476

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:19 → 476

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1148 → 1260

MA3; MA3 domain

pfam02854
Location:671 → 899

MIF4G; MIF4G domain
XM_030249027.2 → XP_030104887.1 eukaryotic translation initiation factor 4 gamma 1 isoform X17

UniProtKB/TrEMBL

A0A0J9YUS5

Conserved Domains (4) summary

cd11559
Location:1338 → 1467

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:19 → 466

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1139 → 1251

MA3; MA3 domain

pfam02854
Location:662 → 890

MIF4G; MIF4G domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001005331.1: Suppressed sequence

Description

NM_001005331.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.