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    CREB3L4 cAMP responsive element binding protein 3 like 4 [ Homo sapiens (human) ]

    Gene ID: 148327, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CREB3L4provided by HGNC
    Official Full Name
    cAMP responsive element binding protein 3 like 4provided by HGNC
    Primary source
    HGNC:HGNC:18854
    See related
    Ensembl:ENSG00000143578 MIM:607138; AllianceGenome:HGNC:18854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
    Summary
    This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CREB3L4 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153967487..153974359)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153104744..153111622)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153940378..153946835)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1762 Neighboring gene solute carrier family 39 member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:153935601-153936800 Neighboring gene microRNA 6737 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153939664-153940520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153948322-153948971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153949621-153950269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1770 Neighboring gene Sharpr-MPRA regulatory region 11874 Neighboring gene jumping translocation breakpoint Neighboring gene JTB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1771 Neighboring gene RAB13, member RAS oncogene family Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153958417-153958918 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:153962963-153964162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma. Pu Q, et al. J Mammary Gland Biol Neoplasia, 2020 Mar. PMID 32026099
    2. The role of CREB3L4 in the proliferation of prostate cancer cells. Kim TH, et al. Sci Rep, 2017 Mar 24. PMID 28338058, Free PMC Article
    3. Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. Ben Aicha S, et al. Physiol Genomics, 2007 Oct 22. PMID 17712038
    4. Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4). Cao G, et al. J Hum Genet, 2002. PMID 12111373
    5. Overexpression of MUC1 predicts poor prognosis in patients with breast cancer. Jing X, et al. Oncol Rep, 2019 Feb. PMID 30483806, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer.
      Title: AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer.
    2. MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
      Title: MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
    3. The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma.
      Title: The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma.
    4. Study demonstrated that MCU1 is frequently overexpressed in breast cancer and abnormally high expression of MUC1 indicates poor prognosis. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression CREB3L4 in breast cancer tissues. Results indicated that MUC1 transcript expression may regulate tumor invasion and metastasis associated with CREB3L4 transcription.
      Title: Overexpression of MUC1 predicts poor prognosis in patients with breast cancer.
    5. CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding.
      Title: The role of CREB3L4 in the proliferation of prostate cancer cells.
    6. AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells.
      Title: The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression.
    7. In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis.
      Title: Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells.
    8. identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues
      Title: Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4).
    9. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells.
      Title: AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells.
    10. S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region
      Title: CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 3-like protein 4
    Names
    Androgen-Induced bZIP
    CREB-4
    androgen-induced basic leucine zipper protein
    attaching to CRE-like 1
    cAMP responsive element binding protein 1
    cAMP-responsive element-binding protein 3-like protein 4
    cAMP-responsive element-binding protein 4
    cyclic AMP-responsive element-binding protein 4
    tisp40
    transcript induced in spermiogenesis protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001255978.2 → NP_001242907.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AY049977, DB012316
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Related
      ENSP00000357596.3, ENST00000368607.8
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    2. NM_001255979.2 → NP_001242908.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA652478, AF394167, AF468007
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Related
      ENSP00000357592.1, ENST00000368603.5
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001255980.2 → NP_001242909.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001242909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
      Source sequence(s)
      AA652478, AK304665, DB012316
      Consensus CDS
      CCDS58029.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198 → 258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001255981.2 → NP_001242910.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001242910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
      Source sequence(s)
      AL358472, BX647716
      Consensus CDS
      CCDS58029.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Related
      ENSP00000357589.3, ENST00000368600.7
      Conserved Domains (1) summary
      cd14689
      Location:198 → 258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    5. NM_130898.4 → NP_570968.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_570968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA652478, AB052778, DB012316
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Related
      ENSP00000271889.4, ENST00000271889.8
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    RNA

    1. NR_045658.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA652478, AK297703, BF681098, DB012316

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153967487..153974359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453343.2 → XP_024309111.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    2. XM_047446827.1 → XP_047302783.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    3. XM_024453344.2 → XP_024309112.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    4. XM_017000372.2 → XP_016855861.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198 → 258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    5. XM_006711172.3 → XP_006711235.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006711235.1

      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198 → 258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    6. XM_024453346.2 → XP_024309114.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
      Conserved Domains (2) summary
      TIGR00864
      Location:77 → 154
      PCC; polycystin cation channel protein
      cd14689
      Location:218 → 278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153104744..153111622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334550.1 → XP_054190525.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5

    2. XM_054334551.1 → XP_054190526.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5

    3. XM_054334555.1 → XP_054190530.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    4. XM_054334554.1 → XP_054190529.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    5. XM_054334553.1 → XP_054190528.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    6. XM_054334552.1 → XP_054190527.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D3DV62, Q5T4L0, Q86YW6, Q8TEY5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEY5.1 GenPept UniProtKB/Swiss-Prot:Q8TEY5

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