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    FAM83F family with sequence similarity 83 member F [ Homo sapiens (human) ]

    Gene ID: 113828, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FAM83Fprovided by HGNC
    Official Full Name
    family with sequence similarity 83 member Fprovided by HGNC
    Primary source
    HGNC:HGNC:25148
    See related
    Ensembl:ENSG00000133477 AllianceGenome:HGNC:25148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 11.4), skin (RPKM 5.5) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM83F in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39994954..40043534)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (40465916..40515097)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (40390958..40439538)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene GRB2 related adaptor protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:40361232-40361409 Neighboring gene uncharacterized LOC124905155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40390673-40391306 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40393419-40394024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40394025-40394630 Neighboring gene translation machinery associated 7 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401347-40401848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401849-40402348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40418684-40419184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40419185-40419685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19079 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40426725-40427244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:40439529-40440176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13767 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:40442874-40443092 Neighboring gene TNRC6B divergent transcript Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:40497428-40497948 Neighboring gene ribosomal protein L7 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19082 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40591286-40591820 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40591821-40592353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40624195-40624696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40633809-40634710 Neighboring gene uncharacterized LOC124905121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Highly Expressed FAM83F Protein in Papillary Thyroid Cancer Exerts a Pro-Oncogenic Role in Thyroid Follicular Cells. Fuziwara CS, et al. Front Endocrinol (Lausanne), 2019. PMID 30881348, Free PMC Article
    2. Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis. Tai G, et al. Exp Lung Res, 2021 Apr. PMID 33560141
    3. FAM83F regulates canonical Wnt signalling through an interaction with CK1α. Dunbar K, et al. Life Sci Alliance, 2021 Feb. PMID 33361109, Free PMC Article
    4. MiR-650 inhibits the progression of glioma by targeting FAM83F. Xu L, et al. Eur Rev Med Pharmacol Sci, 2018 Dec. PMID 30556880
    5. MiR-940 inhibits the progression of NSCLC by targeting FAM83F. Gu GM, et al. Eur Rev Med Pharmacol Sci, 2018 Sep. PMID 30280778

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis.
      Title: Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis.
    2. FAM83F regulates canonical Wnt signalling through an interaction with CK1alpha.
      Title: FAM83F regulates canonical Wnt signalling through an interaction with CK1α.
    3. MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F.
      Title: MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F.
    4. Fam83F induces p53 stabilisation and promotes its activity.
      Title: Fam83F induces p53 stabilisation and promotes its activity.
    5. Results show that FAM83F expression was distinctly upregulated in non-small cell lung cancer (NSCLC) tissues. MiR-940 inhibited the proliferation of cancer cells by targeting FAM83F and further restrained the progression of NSCLC.
      Title: MiR-940 inhibits the progression of NSCLC by targeting FAM83F.
    6. Low MiR-650 expression in glioma cells promotes tumor cell proliferation by up-regulating the expression of FAM83F.
      Title: MiR-650 inhibits the progression of glioma by targeting FAM83F.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM83F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138435.4 → NP_612444.2  protein FAM83F

      See identical proteins and their annotated locations for NP_612444.2

      Status: VALIDATED

      Source sequence(s)
      KF457465, Z82206, Z83847
      Consensus CDS
      CCDS14000.2
      UniProtKB/Swiss-Prot
      Q8NEG4, Q96FD6
      Related
      ENSP00000330432.5, ENST00000333407.11
      Conserved Domains (2) summary
      cd09186
      Location:20 → 295
      PLDc_FAM83F_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83F
      pfam13091
      Location:154 → 291
      PLDc_2; PLD-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      39994954..40043534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      40465916..40515097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_039988.1: Suppressed sequence

      Description
      NR_039988.1: This RefSeq was removed because the gene was discontinued.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEG4.1 GenPept UniProtKB/Swiss-Prot:Q8NEG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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