Cd37 CD37 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd37provided by RGD
Official Full Name: CD37 moleculeprovided by RGD
Primary source: RGD:62035
See related: Ensembl:ENSRNOG00000020699 AllianceGenome:RGD:62035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to act upstream of or within several processes, including defense response to protozoan; negative regulation of myeloid dendritic cell activation; and positive regulation of immunoglobulin production. Predicted to be located in immunological synapse. Predicted to be integral component of plasma membrane. Orthologous to human CD37 (CD37 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 327.8), Thymus (RPKM 125.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104855622..104861111, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95719171..95724662, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101230470..101236061, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of humoral immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte antigen CD37

Names: CD37 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017124.1 → NP_058820.1 leukocyte antigen CD37

See identical proteins and their annotated locations for NP_058820.1

Status: PROVISIONAL

Source sequence(s)

X53517

UniProtKB/Swiss-Prot

P31053

UniProtKB/TrEMBL

A6JB01, A6JB02

Conserved Domains (1) summary

cd03160
Location:108 → 243

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104855622..104861111 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228981.5 → XP_006229043.1 leukocyte antigen CD37 isoform X3

UniProtKB/TrEMBL

A6JB01

Related

ENSRNOP00000059092.3

Conserved Domains (2) summary

cd03160
Location:131 → 266

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:49 → 293

Tetraspannin; Tetraspanin family
XM_017588850.3 → XP_017444339.1 leukocyte antigen CD37 isoform X1
XM_017588851.3 → XP_017444340.1 leukocyte antigen CD37 isoform X2