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    Dzip3 DAZ interacting zinc finger protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303963, updated on 2-May-2024

    Summary

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    Official Symbol
    Dzip3provided by RGD
    Official Full Name
    DAZ interacting zinc finger protein 3provided by RGD
    Primary source
    RGD:1563278
    See related
    Ensembl:ENSRNOG00000001956 AllianceGenome:RGD:1563278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563278
    Summary
    Predicted to enable several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in cytoplasm. Orthologous to human DZIP3 (DAZ interacting zinc finger protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 191.7), Heart (RPKM 78.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dzip3 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (65286190..65356314)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (51823235..51893353)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (54404777..54475361)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene myosin, heavy chain 15 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene cellular inhibitor of PP2A Neighboring gene resistin-like gamma Neighboring gene resistin like alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. Kreft SG, et al. J Cell Sci, 2003 Feb 15. PMID 12538761
    2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DZIP3
    Names
    DAZ interacting protein 3, zinc finger
    NP_001414012.1
    XP_006248351.1
    XP_017453641.1
    XP_017453642.1
    XP_017453643.1
    XP_017453644.1
    XP_038944800.1
    XP_038944801.1
    XP_038944802.1
    XP_063126601.1
    XP_063126602.1
    XP_063126603.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427083.1 → NP_001414012.1  E3 ubiquitin-protein ligase DZIP3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      65286190..65356314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270531.1 → XP_063126601.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    2. XM_017598152.3 → XP_017453641.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABW2
      Conserved Domains (2) summary
      pfam12678
      Location:1143 → 1184
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:1144 → 1184
      zf-RING_2; Ring finger domain

    3. XM_017598153.2 → XP_017453642.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABW2, D4A1V8
      Related
      ENSRNOP00000002678.7, ENSRNOT00000002678.9

    4. XM_063270532.1 → XP_063126602.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ABS6

    5. XM_017598155.2 → XP_017453644.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABW2, A6IQV3
      Related
      ENSRNOP00000089459.1, ENSRNOT00000099511.1
      Conserved Domains (2) summary
      pfam12678
      Location:937 → 978
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:938 → 978
      zf-RING_2; Ring finger domain

    6. XM_039088873.2 → XP_038944801.1  E3 ubiquitin-protein ligase DZIP3 isoform X8

      Conserved Domains (2) summary
      pfam18738
      Location:419 → 564
      HEPN_DZIP3; DZIP3/ hRUL138-like HEPN
      pfam19179
      Location:252 → 336
      DUF5861; Family of unknown function (DUF5861)

    7. XM_063270533.1 → XP_063126603.1  E3 ubiquitin-protein ligase DZIP3 isoform X7

    8. XM_006248289.5 → XP_006248351.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_006248351.1

      UniProtKB/TrEMBL
      A0A8I6ABW2
      Conserved Domains (2) summary
      pfam12678
      Location:1143 → 1184
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:1144 → 1184
      zf-RING_2; Ring finger domain

    9. XM_017598154.3 → XP_017453643.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ABW2

    10. XM_039088872.1 → XP_038944800.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

      Conserved Domains (4) summary
      COG1196
      Location:243 → 497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:660 → 837
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:796 → 837
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      pfam18738
      Location:72 → 217
      HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

    11. XM_039088874.1 → XP_038944802.1  E3 ubiquitin-protein ligase DZIP3 isoform X9

      Conserved Domains (3) summary
      COG1196
      Location:37 → 291
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:454 → 631
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:590 → 631
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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