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    RPL38 ribosomal protein L38 [ Homo sapiens (human) ]

    Gene ID: 6169, updated on 5-May-2024

    Summary

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    Official Symbol
    RPL38provided by HGNC
    Official Full Name
    ribosomal protein L38provided by HGNC
    Primary source
    HGNC:HGNC:10349
    See related
    Ensembl:ENSG00000172809 MIM:604182; AllianceGenome:HGNC:10349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L38; eL38
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 645.4), fat (RPKM 429.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL38 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74203678..74210655)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75094516..75101493)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72199817..72206794)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985081 Neighboring gene uncharacterized LOC105371888 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:71970489-71971186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71969789-71970488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71983339-71984178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72001833-72002829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72005404-72005904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72037304-72037804 Neighboring gene long intergenic non-protein coding RNA 2074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72076663-72077162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72076161-72076662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72145665-72146166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72147681-72148235 Neighboring gene NANOG hESC enhancer GRCh37_chr17:72159526-72160027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72176106-72176682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72178385-72178885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72192568-72193068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72193069-72193569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72199053-72199556 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72200565-72201069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72201070-72201573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72220111-72220644 Neighboring gene uncharacterized protein MGC16275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72241021-72241915 Neighboring gene tweety family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72280764-72281359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72285237-72285737 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:72292700-72292934 Neighboring gene uncharacterized LOC105371891 Neighboring gene dynein axonemal intermediate chain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes. Gopanenko AV, et al. Int J Mol Sci, 2021 Apr 26. PMID 33926116, Free PMC Article
    2. Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription. Gopanenko AV, et al. Biochimie, 2021 May. PMID 33675855
    3. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. Espinosa L, et al. Biochim Biophys Acta, 1997 Oct 9. PMID 9375793
    4. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Bayés A, et al. Nat Neurosci, 2011 Jan. PMID 21170055, Free PMC Article
    5. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. Uechi T, et al. Genomics, 2001 Mar 15. PMID 11401437

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and bioinformatics analysis of RPL38 protein and mRNA in gastric cancer.
      Title: Expression and bioinformatics analysis of RPL38 protein and mRNA in gastric cancer.
    2. Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription.
      Title: Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription.
    3. Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes.
      Title: Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 90S preribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in middle ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-RNA complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic 80S initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL38
    Names
    60S ribosomal protein L38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000999.4 → NP_000990.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_000990.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer and predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC100786, BQ276548, CB124619, Z26876
      Consensus CDS
      CCDS11696.1
      UniProtKB/Swiss-Prot
      B2R5A8, P23411, P63173
      UniProtKB/TrEMBL
      J3QL01
      Related
      ENSP00000309830.6, ENST00000311111.11
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    2. NM_001035258.2 → NP_001030335.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_001030335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is the shorter transcript, lacking a segment in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC100786, CB128529
      Consensus CDS
      CCDS11696.1
      UniProtKB/Swiss-Prot
      B2R5A8, P23411, P63173
      UniProtKB/TrEMBL
      J3QL01
      Related
      ENSP00000390279.2, ENST00000439590.6
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74203678..74210655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75094516..75101493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63173.2 GenPept UniProtKB/Swiss-Prot:P63173

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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