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    CACNA1A calcium voltage-gated channel subunit alpha1 A [ Bos taurus (cattle) ]

    Gene ID: 282648, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CACNA1Aprovided by VGNC
    Official Full Name
    calcium voltage-gated channel subunit alpha1 Aprovided by VGNC
    Primary source
    VGNC:VGNC:26672
    See related
    Ensembl:ENSBTAG00000014828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CAV2.1
    Orthologs
    human mouse all
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    Genomic context

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    See CACNA1A in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (12144006..12397316)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS14-like Neighboring gene mitochondrial transcription rescue factor 1-like Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene uncharacterized LOC112447340 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene microRNA mir-12000 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene syntaxin 10 Neighboring gene immediate early response 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of endogenous N- and P/Q-type Ca2+ channel inactivation by Ca2+/calmodulin impacts on their ability to support exocytosis in chromaffin cells. Wykes RC, et al. J Neurosci, 2007 May 9. PMID 17494710, Free PMC Article
    2. Bovine CACNA1A gene and comparative analysis of the CAG repeats associated to human spinocerebellar ataxia type-6. Andrés-Mateos E, et al. Gene, 2006 Sep 15. PMID 16876337
    3. Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation. Peruffo A, et al. Neurosci Lett, 2013 Nov 27. PMID 24148303
    4. Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells. Andrés-Mateos E, et al. Eur J Neurosci, 2005 Nov. PMID 16262657
    5. Differential expression of calcium channel subtypes in the bovine adrenal medulla. García-Palomero E, et al. Neuroendocrinology, 2001 Oct. PMID 11598381

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.
      Title: Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation.
    2. cloned the full-length alpha1A subunit
      Title: Bovine CACNA1A gene and comparative analysis of the CAG repeats associated to human spinocerebellar ataxia type-6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent P/Q-type calcium channel subunit alpha-1A
    Names
    calcium channel, alpha 1A subunit
    calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    voltage-gated calcium channel alpha 1A subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075129.1 → NP_001068597.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A

      See identical proteins and their annotated locations for NP_001068597.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ207750
      UniProtKB/TrEMBL
      F1N1E0, Q1ADE8
      Related
      ENSBTAP00000019752.6, ENSBTAT00000019752.7
      Conserved Domains (4) summary
      pfam00520
      Location:1585 → 1824
      Ion_trans; Ion transport protein
      pfam08763
      Location:1897 → 1971
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10630
      Location:2332 → 2392
      DUF2476; Protein of unknown function (DUF2476)
      pfam16905
      Location:1832 → 1895
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      12144006..12397316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993853.2 → XP_024849621.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X6

      UniProtKB/TrEMBL
      F1N1E0
      Related
      ENSBTAP00000088292.1, ENSBTAT00000099739.1
      Conserved Domains (5) summary
      pfam00520
      Location:1565 → 1822
      Ion_trans; Ion transport protein
      pfam08763
      Location:1895 → 1969
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1823 → 1893
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl28033
      Location:1996 → 2408
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
      cl28310
      Location:767 → 991
      Rho; Transcription termination factor Rho [Transcription]

    2. XM_059887937.1 → XP_059743920.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2

    3. XM_059887936.1 → XP_059743919.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1

    4. XM_059887938.1 → XP_059743921.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3

    5. XM_059887939.1 → XP_059743922.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4

    6. XM_059887940.1 → XP_059743923.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5

      Related
      ENSBTAP00000058208.2, ENSBTAT00000074041.2
    Nucleotide Protein Strain
    Heading Accession and Version

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