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    UBR5 ubiquitin protein ligase E3 component n-recognin 5 [ Gallus gallus (chicken) ]

    Gene ID: 420252, updated on 6-Jun-2024

    Summary

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    Symbol
    UBR5provided by CGNC
    Full Name
    ubiquitin protein ligase E3 component n-recognin 5provided by CGNC
    Primary source
    CGNC:51215
    See related
    Ensembl:ENSGALG00010012024
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    EDD1
    Orthologs
    human mouse all
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    Genomic context

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    See UBR5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (128685420..128765183, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (128892199..128972085, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751294 Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B Neighboring gene outer dense fiber of sperm tails 1 Neighboring gene Kruppel-like factor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR5
    Names
    E3 ubiquitin protein ligase, HECT domain containing, 1
    XP_040519506.1
    XP_040519507.1
    XP_040519508.1
    XP_040519509.1
    XP_040519510.1
    XP_040519511.1
    XP_040519512.1
    XP_040519513.1
    XP_040519514.1
    XP_040519515.1
    XP_040519516.1
    XP_040552307.1
    XP_040552308.1
    XP_040552309.1
    XP_040552310.1
    XP_040552311.1
    XP_040552312.1
    XP_040552313.1
    XP_040552314.1
    XP_040552315.1
    XP_040552316.1
    XP_040552317.1
    XP_046768017.1
    XP_046793924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      128685420..128765183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040696383.2 → XP_040552317.1  E3 ubiquitin-protein ligase UBR5 isoform X12

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1146 → 1213
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2365 → 2428
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2443 → 2771
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:144 → 186
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    2. XM_040696382.2 → XP_040552316.1  E3 ubiquitin-protein ligase UBR5 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1152 → 1219
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2371 → 2434
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2449 → 2777
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:144 → 186
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    3. XM_040696381.2 → XP_040552315.1  E3 ubiquitin-protein ligase UBR5 isoform X10

      UniProtKB/TrEMBL
      A0A8V0YDJ7, A0A8V0YFR9
      Related
      ENSGALP00010016583.1, ENSGALT00010028821.1
      Conserved Domains (4) summary
      smart00396
      Location:1171 → 1238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2383 → 2446
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2461 → 2789
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    4. XM_040696376.2 → XP_040552310.1  E3 ubiquitin-protein ligase UBR5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1186 → 1253
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2405 → 2468
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2483 → 2811
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    5. XM_040696380.2 → XP_040552314.1  E3 ubiquitin-protein ligase UBR5 isoform X9

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2389 → 2452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2467 → 2795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    6. XM_040696378.2 → XP_040552312.1  E3 ubiquitin-protein ligase UBR5 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2396 → 2459
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2474 → 2802
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    7. XM_040696379.2 → XP_040552313.1  E3 ubiquitin-protein ligase UBR5 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1175 → 1242
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2394 → 2457
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2472 → 2800
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    8. XM_040696374.2 → XP_040552308.1  E3 ubiquitin-protein ligase UBR5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2409 → 2472
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2487 → 2815
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    9. XM_046937968.1 → XP_046793924.1  E3 ubiquitin-protein ligase UBR5 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YDJ7

    10. XM_040696377.2 → XP_040552311.1  E3 ubiquitin-protein ligase UBR5 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Related
      ENSGALP00010016577.1, ENSGALT00010028811.1
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2404 → 2467
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2482 → 2810
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    11. XM_040696375.2 → XP_040552309.1  E3 ubiquitin-protein ligase UBR5 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2408 → 2471
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2486 → 2814
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    12. XM_040696373.2 → XP_040552307.1  E3 ubiquitin-protein ligase UBR5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2411 → 2474
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2489 → 2817
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      128892199..128972085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040663582.2 → XP_040519516.1  E3 ubiquitin-protein ligase UBR5 isoform X12

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1146 → 1213
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2365 → 2428
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2443 → 2771
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:144 → 186
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    2. XM_040663581.2 → XP_040519515.1  E3 ubiquitin-protein ligase UBR5 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1152 → 1219
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2371 → 2434
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2449 → 2777
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:144 → 186
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    3. XM_040663580.2 → XP_040519514.1  E3 ubiquitin-protein ligase UBR5 isoform X10

      UniProtKB/TrEMBL
      A0A8V0YDJ7, A0A8V0YFR9
      Conserved Domains (4) summary
      smart00396
      Location:1171 → 1238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2383 → 2446
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2461 → 2789
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    4. XM_040663575.2 → XP_040519509.1  E3 ubiquitin-protein ligase UBR5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1186 → 1253
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2405 → 2468
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2483 → 2811
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    5. XM_040663579.2 → XP_040519513.1  E3 ubiquitin-protein ligase UBR5 isoform X9

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2389 → 2452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2467 → 2795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    6. XM_040663577.2 → XP_040519511.1  E3 ubiquitin-protein ligase UBR5 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2396 → 2459
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2474 → 2802
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    7. XM_040663578.2 → XP_040519512.1  E3 ubiquitin-protein ligase UBR5 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1175 → 1242
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2394 → 2457
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2472 → 2800
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    8. XM_040663573.2 → XP_040519507.1  E3 ubiquitin-protein ligase UBR5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2409 → 2472
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2487 → 2815
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    9. XM_046912061.1 → XP_046768017.1  E3 ubiquitin-protein ligase UBR5 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YDJ7

    10. XM_040663576.2 → XP_040519510.1  E3 ubiquitin-protein ligase UBR5 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2404 → 2467
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2482 → 2810
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    11. XM_040663574.2 → XP_040519508.1  E3 ubiquitin-protein ligase UBR5 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2408 → 2471
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2486 → 2814
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    12. XM_040663572.2 → XP_040519506.1  E3 ubiquitin-protein ligase UBR5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YDJ7
      Conserved Domains (4) summary
      smart00396
      Location:1192 → 1259
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2411 → 2474
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2489 → 2817
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 226
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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