UNC5B unc-5 netrin receptor B [Gallus gallus (chicken)] - Gene

Summary

Symbol: UNC5Bprovided by CGNC
Full Name: unc-5 netrin receptor Bprovided by CGNC
Primary source: CGNC:52034
See related: Ensembl:ENSGALG00010020365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (12474900..12505789)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (12520869..12551763)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Netrin-1 expressing cells inhibited angiogenic sprouting of unc5b expressing blood vessels, but had no pro-angiogenic activity at any stage of development examined.
Title: Netrin-1 inhibits sprouting angiogenesis in developing avian embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: netrin receptor UNC5B

Names: UNC5H2; unc-5 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031225.3 → NP_001026396.2 netrin receptor UNC5B precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000230

UniProtKB/TrEMBL

E1C228, Q5K6J8

Related

ENSGALP00010029099.1, ENSGALT00010049218.1

Conserved Domains (5) summary

smart00218
Location:543 → 645

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:858 → 941

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:250 → 301

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:156 → 244

I-set; Immunoglobulin I-set domain

cl11960
Location:158 → 244

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12474900..12505789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025151567.3 → XP_025007335.1 netrin receptor UNC5B isoform X1

UniProtKB/TrEMBL

A0A3Q2TWV0, Q5K6J8

Related

ENSGALP00010029097.1, ENSGALT00010049212.1

Conserved Domains (5) summary

smart00218
Location:532 → 634

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:847 → 930

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:250 → 301

TSP1; Thrombospondin type 1 repeats

pfam17217
Location:681 → 820

UPA; UPA domain

cl11960
Location:158 → 244

Ig; Immunoglobulin domain