U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACTN1 actinin, alpha 1 [ Gallus gallus (chicken) ]

    Gene ID: 373918, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ACTN1provided by CGNC
    Official Full Name
    actinin, alpha 1provided by CGNC
    Primary source
    CGNC:48956
    See related
    Ensembl:ENSGALG00010020389
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ACTN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (27732414..27814071)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (27692305..27773943)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene uncharacterized LOC121110868 Neighboring gene uncharacterized LOC112532527 Neighboring gene serine/arginine-rich splicing factor 5a Neighboring gene microRNA 1617

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and characterization of a cDNA encoding a chick alpha-actinin. Baron MD, et al. J Biol Chem, 1987 Feb 25. PMID 3818609
    2. The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin. Baron MD, et al. J Biol Chem, 1987 Dec 25. PMID 2826427
    3. Mutually exclusive splicing of calcium-binding domain exons in chick alpha-actinin. Waites GT, et al. J Biol Chem, 1992 Mar 25. PMID 1556133
    4. Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes. Zhang ZQ, et al. Exp Cell Res, 2009 Mar 10. PMID 19166831
    5. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. Pomiès P, et al. J Cell Biol, 1997 Oct 6. PMID 9314536, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A critical region of s-alpha-actinin that affects the width and integrity of the Z-line. This region is at least involved in the interaction with vinculin.
      Title: Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-actinin-1
    Names
    F-actin cross-linking protein
    non-muscle alpha-actinin-1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204127.2 → NP_989458.2  alpha-actinin-1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000214
      UniProtKB/TrEMBL
      A0A8V0ZKK8
      Related
      ENSGALP00010029143.1, ENSGALT00010049295.1
      Conserved Domains (6) summary
      COG5126
      Location:744 → 888
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:396 → 623
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:635 → 734
      Spectrin; Spectrin repeat
      pfam08726
      Location:818 → 884
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:29 → 133
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:137 → 251
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      27732414..27814071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015287257.4 → XP_015142743.1  alpha-actinin-1 isoform X5

      UniProtKB/TrEMBL
      A0A1D5P9P3, A0A8V0ZKK8
      Related
      ENSGALP00010029158.1, ENSGALT00010049315.1
      Conserved Domains (6) summary
      cd00051
      Location:751 → 840
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:396 → 623
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:635 → 734
      Spectrin; Spectrin repeat
      pfam08726
      Location:845 → 911
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:29 → 133
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:137 → 251
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    2. XM_015287258.4 → XP_015142744.1  alpha-actinin-1 isoform X1

      UniProtKB/Swiss-Prot
      P05094, Q99001
      UniProtKB/TrEMBL
      A0A8V0ZKK8
      Related
      ENSGALP00010029162.1, ENSGALT00010049325.1
      Conserved Domains (6) summary
      cd00051
      Location:751 → 818
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:396 → 623
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:635 → 734
      Spectrin; Spectrin repeat
      pfam08726
      Location:823 → 889
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:29 → 133
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:137 → 251
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    3. XM_046941334.1 → XP_046797290.1  alpha-actinin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZKK8
      Related
      ENSGALP00010029166.1, ENSGALT00010049333.1

    4. XM_046941335.1 → XP_046797291.1  alpha-actinin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZD41, A0A8V0ZKK8
      Related
      ENSGALP00010029139.1, ENSGALT00010049290.1

    5. XM_046941336.1 → XP_046797292.1  alpha-actinin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZKK8

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      27692305..27773943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917605.1 → XP_046773561.1  alpha-actinin-1 isoform X5

      UniProtKB/TrEMBL
      A0A1D5P9P3, A0A8V0ZKK8

    2. XM_046917601.1 → XP_046773557.1  alpha-actinin-1 isoform X1

      UniProtKB/Swiss-Prot
      P05094, Q99001
      UniProtKB/TrEMBL
      A0A8V0ZKK8

    3. XM_046917602.1 → XP_046773558.1  alpha-actinin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZKK8

    4. XM_046917603.1 → XP_046773559.1  alpha-actinin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZD41, A0A8V0ZKK8

    5. XM_046917604.1 → XP_046773560.1  alpha-actinin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZKK8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05094.3 GenPept UniProtKB/Swiss-Prot:P05094

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.