CRB2 crumbs 2, cell polarity complex component [Gallus gallus (chicken)] - Gene

Summary

Symbol: CRB2provided by CGNC
Full Name: crumbs 2, cell polarity complex componentprovided by CGNC
Primary source: CGNC:50440
See related: Ensembl:ENSGALG00010028326
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	17	NC_052548.1 (9560600..9626663)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	17	NC_052589.1 (8971124..9040641)

Chromosome 17 - NC_052548.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein crumbs homolog 2

Names: crumbs family member 2; crumbs homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9560600..9626663

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015279573.4 → XP_015135059.1 protein crumbs homolog 2 isoform X3

UniProtKB/TrEMBL

A0A8V1ADD1

Conserved Domains (5) summary

smart00179
Location:416 → 444

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:129 → 165

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:503 → 664

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:691 → 720

EGF; EGF-like domain

pfam02210
Location:758 → 875

Laminin_G_2; Laminin G domain
XM_004946009.5 → XP_004946066.1 protein crumbs homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8V1ADD1, E1BYW1

Related

ENSGALP00010042178.1, ENSGALT00010068588.1

Conserved Domains (5) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:749 → 778

EGF; EGF-like domain

pfam02210
Location:816 → 933

Laminin_G_2; Laminin G domain
XM_004946010.5 → XP_004946067.1 protein crumbs homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8V1ADD1, A0A8V1AI95

Related

ENSGALP00010042180.1, ENSGALT00010068593.1

Conserved Domains (5) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:749 → 778

EGF; EGF-like domain

pfam02210
Location:816 → 933

Laminin_G_2; Laminin G domain
XM_040649129.2 → XP_040505063.1 protein crumbs homolog 2 isoform X4

UniProtKB/TrEMBL

A0A8V1ADD1

Conserved Domains (3) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

XR_005840395.2 RNA Sequence
XR_003070956.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

8971124..9040641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040685515.2 → XP_040541449.1 protein crumbs homolog 2 isoform X3

UniProtKB/TrEMBL

A0A8V1ADD1

Conserved Domains (5) summary

smart00179
Location:416 → 444

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:129 → 165

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:503 → 664

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:691 → 720

EGF; EGF-like domain

pfam02210
Location:758 → 875

Laminin_G_2; Laminin G domain
XM_040685513.2 → XP_040541447.1 protein crumbs homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8V1ADD1, E1BYW1

Conserved Domains (5) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:749 → 778

EGF; EGF-like domain

pfam02210
Location:816 → 933

Laminin_G_2; Laminin G domain
XM_040685514.2 → XP_040541448.1 protein crumbs homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8V1ADD1, A0A8V1AI95

Conserved Domains (5) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:749 → 778

EGF; EGF-like domain

pfam02210
Location:816 → 933

Laminin_G_2; Laminin G domain
XM_040685516.2 → XP_040541450.1 protein crumbs homolog 2 isoform X4

UniProtKB/TrEMBL

A0A8V1ADD1

Conserved Domains (3) summary

smart00179
Location:474 → 502

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:187 → 223

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:561 → 722

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...