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    brd3b bromodomain containing 3b [ Danio rerio (zebrafish) ]

    Gene ID: 327108, updated on 25-Apr-2024

    Summary

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    Official Symbol
    brd3bprovided by ZNC
    Official Full Name
    bromodomain containing 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5316
    See related
    Ensembl:ENSDARG00000100129 AllianceGenome:ZFIN:ZDB-GENE-030131-5316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa28f05; zgc:77289; wu:fa28f05; wu:fc56a11; wu:fj66d12
    Summary
    Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See brd3b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (64411849..64454466, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (63730841..63773297, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 7a (inactive) Neighboring gene endothelial differentiation-related factor 1 Neighboring gene retinoid x receptor, alpha b Neighboring gene prostate stem cell antigen-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
    2. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Ko S, et al. J Hepatol, 2016 Feb. PMID 26505118, Free PMC Article
    3. Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration. He J, et al. Hepatology, 2019 Dec. PMID 31136010
    4. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    5. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 3; bromodomain-containing protein 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212702.1 → NP_997867.1  bromodomain-containing protein 3b

      See identical proteins and their annotated locations for NP_997867.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065949
      UniProtKB/TrEMBL
      Q6NZW1
      Related
      ENSDARP00000129878.1, ENSDART00000168030.2
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:551 → 615
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      64411849..64454466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165594.4 → XP_005165651.2  bromodomain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCY3
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:293 → 394
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:573 → 637
      BET; Bromodomain extra-terminal - transcription regulation

    2. XM_005165595.4 → XP_005165652.2  bromodomain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BCV5
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:551 → 615
      BET; Bromodomain extra-terminal - transcription regulation

    3. XM_009301940.3 → XP_009300215.1  bromodomain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B2Y4
      Related
      ENSDARP00000141933.1, ENSDART00000172321.2
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:574 → 638
      BET; Bromodomain extra-terminal - transcription regulation

    4. XM_009301936.3 → XP_009300211.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_009300211.1

      UniProtKB/TrEMBL
      A0A8M2BCV6
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:574 → 638
      BET; Bromodomain extra-terminal - transcription regulation

    5. XM_005165593.4 → XP_005165650.2  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005165650.2

      UniProtKB/TrEMBL
      A0A8M2BCV6
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:574 → 638
      BET; Bromodomain extra-terminal - transcription regulation

    6. XM_009301938.3 → XP_009300213.1  bromodomain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M3ASX2
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:551 → 615
      BET; Bromodomain extra-terminal - transcription regulation
    Nucleotide Protein Strain
    Heading Accession and Version

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