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    mavs mitochondrial antiviral signaling protein [ Danio rerio (zebrafish) ]

    Gene ID: 562867, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mavsprovided by ZNC
    Official Full Name
    mitochondrial antiviral signaling proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1402
    See related
    Ensembl:ENSDARG00000069733 AllianceGenome:ZFIN:ZDB-GENE-070112-1402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj20d04; zgc:158392
    Summary
    Enables protein heterodimerization activity. Acts upstream of or within cytoplasmic pattern recognition receptor signaling pathway in response to virus; regulation of transcription, DNA-templated; and response to bacterium. Located in mitochondrion. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mavs in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15182152..15213584)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15051160..15082592)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 5a (class I) Neighboring gene probable G-protein coupled receptor 151 Neighboring gene uncharacterized LOC101885244 Neighboring gene microRNA 103 Neighboring gene pantothenate kinase 2 Neighboring gene lysyl oxidase-like 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish mavs Is Essential for Antiviral Innate Immunity. Ouyang G, et al. J Immunol, 2023 May 1. PMID 36946776
    2. Molecular characterization, ontogeny and expression profiling of mitochondrial antiviral signaling adapter, MAVS from Asian seabass Lates calcarifer, Bloch (1790). Krishnan R, et al. Dev Comp Immunol, 2018 Feb. PMID 29100916
    3. Molecular characterization and expression analysis of mitochondrial antiviral signaling protein gene in sea perch, Lateolabrax japonicus. Jia P, et al. Dev Comp Immunol, 2016 Feb. PMID 26493015
    4. Spring Viremia of Carp Virus N Protein Suppresses Fish IFNφ1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. Lu LF, et al. J Immunol, 2016 May 1. PMID 26994222
    5. Identification and characterization of MAVS from black carp Mylopharyngodon piceus. Zhou W, et al. Fish Shellfish Immunol, 2015 Apr. PMID 25655327

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish mavs Is Essential for Antiviral Innate Immunity.
      Title: Zebrafish mavs Is Essential for Antiviral Innate Immunity.
    2. NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS.
      Title: NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS.
    3. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
      Title: Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7.
    4. Data show that mitochondrial antiviral signaling protein (MAVS) splicing variant 1 (MAVS_tv1) cooperated with DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 RIG-I in the accumulation of RIG-I transcript in a positive feedback loop.
      Title: MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoplasmic pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial antiviral-signaling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080584.2 → NP_001074053.2  mitochondrial antiviral-signaling protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX323842
      UniProtKB/TrEMBL
      A0A8M1NBL7, B8A4W7
      Related
      ENSDARP00000080716.4, ENSDART00000086281.6

    2. NM_001327873.1 → NP_001314802.1  mitochondrial antiviral-signaling protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX323842
      UniProtKB/TrEMBL
      A0A8M9Q9S6, F1REK4
      Related
      ENSDARP00000112479.1, ENSDART00000129045.3
      Conserved Domains (1) summary
      cd08811
      Location:4 → 95
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15182152..15213584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358758.1 → XP_017214247.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9S6, F1REK4
      Related
      ENSDARP00000150370.1, ENSDART00000193644.1
      Conserved Domains (1) summary
      cd08811
      Location:4 → 95
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    2. XM_021480608.1 → XP_021336283.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9S6, F1REK4
      Conserved Domains (1) summary
      cd08811
      Location:4 → 95
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    Nucleotide Protein
    Heading Accession and Version

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