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    hsc70 heat shock cognate 70 [ Danio rerio (zebrafish) ]

    Gene ID: 393586, updated on 27-Mar-2024

    Summary

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    Official Symbol
    hsc70provided by ZNC
    Official Full Name
    heat shock cognate 70provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1221
    See related
    Ensembl:ENSDARG00000012381 AllianceGenome:ZFIN:ZDB-GENE-040426-1221
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63663
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in myotome. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See hsc70 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (37835916..37850961, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (37934331..37949376, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-238d18.3 Neighboring gene chymotrypsin-like Neighboring gene si:dkey-238d18.4 Neighboring gene si:dkey-238d18.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish HSC70 promoter to express carp muscle-specific creatine kinase for acclimation under cold condition. Wu CL, et al. Transgenic Res, 2011 Dec. PMID 21298478
    2. Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. Shu T, et al. Gen Comp Endocrinol, 2020 Sep 1. PMID 32283058
    3. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article
    4. Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). Slade L, et al. J Pharmacol Exp Ther, 2017 Jun. PMID 28385952
    5. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63663

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC393586

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200614.1 → NP_956908.1  uncharacterized protein LOC393586

      See identical proteins and their annotated locations for NP_956908.1

      Status: PREDICTED

      Source sequence(s)
      BC056797
      UniProtKB/Swiss-Prot
      Q90473
      UniProtKB/TrEMBL
      A0A8M1PEQ4, Q6PGX4
      Related
      ENSDARP00000039324.7, ENSDART00000031418.8
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      37835916..37850961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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