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    gsdf gonadal somatic cell derived factor [ Danio rerio (zebrafish) ]

    Gene ID: 571289, updated on 27-Mar-2024

    Summary

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    Official Symbol
    gsdfprovided by ZNC
    Official Full Name
    gonadal somatic cell derived factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101029-3
    See related
    Ensembl:ENSDARG00000075301 AllianceGenome:ZFIN:ZDB-GENE-101029-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable growth factor activity. Acts upstream of or within oocyte maturation. Is expressed in granulosa cell and reproductive system. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gsdf in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (196490..205221)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11830..20561)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 1 Neighboring gene protein phosphatase with EF-hand domain 2b Neighboring gene uncharacterized LOC108180774 Neighboring gene serine/threonine-protein phosphatase with EF-hands 2-like Neighboring gene nucleoporin 54 Neighboring gene brix domain containing 2 Neighboring gene DTW domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra-ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS)
      Title: Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.
    2. evolutionarily conserved DNA motifs may be involved in Sertoli and granulosa cell-specific expression
      Title: The proximal promoter region of the zebrafish gsdf gene is sufficient to mimic the spatio-temporal expression pattern of the endogenous gene in Sertoli and granulosa cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gonadal somatic cell derived factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114668.1 → NP_001108140.1  gonadal somatic cell derived factor precursor

      See identical proteins and their annotated locations for NP_001108140.1

      Status: PROVISIONAL

      Source sequence(s)
      EU378916
      UniProtKB/TrEMBL
      A0A2R8QCF5, B0ZE98, G1CSU3
      Related
      ENSDARP00000149345.1, ENSDART00000193485.1
      Conserved Domains (1) summary
      cl02510
      Location:85 → 157
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      196490..205221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352819.1 → XP_017208308.1  gonadal somatic cell derived factor isoform X2

      UniProtKB/TrEMBL
      A0A2R8QCF5, B0ZE98, G1CSU3
      Conserved Domains (1) summary
      cl02510
      Location:85 → 157
      TGF_beta; Transforming growth factor beta like domain

    2. XM_005173843.4 → XP_005173900.1  gonadal somatic cell derived factor isoform X4

      UniProtKB/TrEMBL
      A0A0R4IHC8, A0A8M2BLI7
      Related
      ENSDARP00000134025.2, ENSDART00000163696.2
      Conserved Domains (1) summary
      cl02510
      Location:84 → 156
      TGF_beta; Transforming growth factor beta like domain

    3. XM_009295053.3 → XP_009293328.1  gonadal somatic cell derived factor isoform X3

      UniProtKB/TrEMBL
      A0A8M3AWI9

    4. XM_003200793.5 → XP_003200841.1  gonadal somatic cell derived factor isoform X1

      UniProtKB/TrEMBL
      A0A8M1RP53
    Nucleotide Protein Strain
    Heading Accession and Version

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