hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd17b4provided by ZNC
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040421-1
See related: Ensembl:ENSDARG00000101239 AllianceGenome:ZFIN:ZDB-GENE-040421-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Dbp; zgc:55545; zgc:77300
Summary: Predicted to enable 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydrogenase activity; and enoyl-CoA hydratase activity. Acts upstream of or within embryonic organ development and neuron development. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (41356..65319, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (190536..214437, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The knockdown of dbp in zebrafish phenocopied clinical manifestations of its deficiency in human.
Title: Developmental roles of D-bifunctional protein-A zebrafish model of peroxisome dysfunction.

Submit: New GeneRIF Correction

General gene information

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Markers

G47020 (e-PCR)
- UniSTS:107812

Z8474 (e-PCR)
- UniSTS:31217

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enoyl-CoA hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisomal multifunctional enzyme type 2

NP_956430.1

EC 1.1.1.n12

EC 4.2.1.107

EC 4.2.1.119

XP_021333882.1

EC 1.1.1.n12

EC 4.2.1.107

EC 4.2.1.119

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200136.1 → NP_956430.1 peroxisomal multifunctional enzyme type 2

See identical proteins and their annotated locations for NP_956430.1

Status: PROVISIONAL

Source sequence(s)

BC044422

UniProtKB/TrEMBL

A0A0R4INZ2, A0A8N7XJ38, B2GSU8, Q8AYH1

Related

ENSDARP00000136011.2, ENSDART00000168412.2

Conserved Domains (6) summary

PLN02864
Location:312 → 603

PLN02864; enoyl-CoA hydratase

cd05353
Location:5 → 254

hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs

PRK05653
Location:6 → 226

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

cd03448
Location:485 → 599

HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.

pfam02036
Location:619 → 720

SCP2; SCP-2 sterol transfer family

cl00509
Location:387 → 445

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

41356..65319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478207.1 → XP_021333882.1 peroxisomal multifunctional enzyme type 2 isoform X1

UniProtKB/TrEMBL

A0A8M9PQQ8

Conserved Domains (3) summary

PLN02864
Location:312 → 603

PLN02864; enoyl-CoA hydratase

cd05353
Location:5 → 254

hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs

pfam02036
Location:643 → 744

SCP2; SCP-2 sterol transfer family