mrpl44 mitochondrial ribosomal protein L44 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mrpl44provided by ZNC
Official Full Name: mitochondrial ribosomal protein L44provided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-59
See related: Ensembl:ENSDARG00000094277 AllianceGenome:ZFIN:ZDB-GENE-050913-59
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114114
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within RNA processing. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (35214546..35224481, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (35356577..35366512, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 39S ribosomal protein L44, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030260.2 → NP_001025431.2 39S ribosomal protein L44, mitochondrial

Status: VALIDATED

Source sequence(s)

CR354553

UniProtKB/TrEMBL

A0A8M1N7N7, F1RB48

Related

ENSDARP00000090374.4, ENSDART00000099600.5

Conserved Domains (2) summary

COG0571
Location:143 → 303

Rnc; dsRNA-specific ribonuclease [Transcription]

cl00054
Location:234 → 302

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...