U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    igf2b insulin-like growth factor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 324215, updated on 1-Jun-2024

    Summary

    Official Symbol
    igf2bprovided by ZNC
    Official Full Name
    insulin-like growth factor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2935
    See related
    Ensembl:ENSDARG00000033307 AllianceGenome:ZFIN:ZDB-GENE-030131-2935
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    igf2a; fc21h08; wu:fc21h08; wu:fc34h12
    Summary
    Enables insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See igf2b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (24039367..24046870, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (23941819..23949322, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized LOC101882916 Neighboring gene si:dkeyp-19e1.3 Neighboring gene tyrosine hydroxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of activated T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor 2b
    Names
    insulin-like growth factor 2a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001815.1NP_001001815.1  insulin-like growth factor 2b precursor

      See identical proteins and their annotated locations for NP_001001815.1

      Status: PROVISIONAL

      Source sequence(s)
      AF250289
      UniProtKB/TrEMBL
      A0A8M1MZM4, Q8JIE4
      Related
      ENSDARP00000047568.4, ENSDART00000047569.5
      Conserved Domains (2) summary
      cd04368
      Location:49115
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:144199
      IGF2_C; Insulin-like growth factor II E-peptide

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      24039367..24046870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395205.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      509049..516583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)